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Senescent cells as thermostats of antitumor immunity.
Prieto LI, Sturmlechner I, Goronzy JJ, Baker DJ. Prieto LI, et al. Among authors: sturmlechner i. Sci Transl Med. 2023 Jun 7;15(699):eadg7291. doi: 10.1126/scitranslmed.adg7291. Epub 2023 Jun 7. Sci Transl Med. 2023. PMID: 37285401 Free PMC article. Review.
Heterogeneity of memory T cells in aging.
Jain A, Sturmlechner I, Weyand CM, Goronzy JJ. Jain A, et al. Among authors: sturmlechner i. Front Immunol. 2023 Aug 18;14:1250916. doi: 10.3389/fimmu.2023.1250916. eCollection 2023. Front Immunol. 2023. PMID: 37662959 Free PMC article. Review.
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. Sturmlechner I, et al. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. Science. 2021. PMID: 34709885 Free PMC article.
Senescent alveolar macrophages promote early-stage lung tumorigenesis.
Prieto LI, Sturmlechner I, Graves SI, Zhang C, Goplen NP, Yi ES, Sun J, Li H, Baker DJ. Prieto LI, et al. Among authors: sturmlechner i. Cancer Cell. 2023 Jul 10;41(7):1261-1275.e6. doi: 10.1016/j.ccell.2023.05.006. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267954
Senescent cells in the development of cardiometabolic disease.
Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK. Postmus AC, et al. Among authors: sturmlechner i. Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602. Curr Opin Lipidol. 2019. PMID: 30913069 Free PMC article. Review.
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.
Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH. Cherry C, et al. Among authors: sturmlechner i. Geroscience. 2023 Aug;45(4):2559-2587. doi: 10.1007/s11357-023-00785-7. Epub 2023 Apr 20. Geroscience. 2023. PMID: 37079217 Free PMC article.
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