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Complete human day 14 post-implantation embryo models from naive ES cells.
Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N, Hanna JH. Oldak B, et al. Among authors: novershtern n. Nature. 2023 Oct;622(7983):562-573. doi: 10.1038/s41586-023-06604-5. Epub 2023 Sep 6. Nature. 2023. PMID: 37673118 Free PMC article.
Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis.
Aguilera-Castrejon A, Oldak B, Shani T, Ghanem N, Itzkovich C, Slomovich S, Tarazi S, Bayerl J, Chugaeva V, Ayyash M, Ashouokhi S, Sheban D, Livnat N, Lasman L, Viukov S, Zerbib M, Addadi Y, Rais Y, Cheng S, Stelzer Y, Keren-Shaul H, Shlomo R, Massarwa R, Novershtern N, Maza I, Hanna JH. Aguilera-Castrejon A, et al. Among authors: novershtern n. Nature. 2021 May;593(7857):119-124. doi: 10.1038/s41586-021-03416-3. Epub 2021 Mar 17. Nature. 2021. PMID: 33731940
Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.
Tarazi S, Aguilera-Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, Wildschutz E, Haddad M, Oldak B, Gomez-Cesar E, Livnat N, Viukov S, Lokshtanov D, Naveh-Tassa S, Rose M, Hanna S, Raanan C, Brenner O, Kedmi M, Keren-Shaul H, Lapidot T, Maza I, Novershtern N, Hanna JH. Tarazi S, et al. Among authors: novershtern n. Cell. 2022 Sep 1;185(18):3290-3306.e25. doi: 10.1016/j.cell.2022.07.028. Epub 2022 Aug 1. Cell. 2022. PMID: 35988542 Free PMC article.
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells.
Viukov S, Shani T, Bayerl J, Aguilera-Castrejon A, Oldak B, Sheban D, Tarazi S, Stelzer Y, Hanna JH, Novershtern N. Viukov S, et al. Among authors: novershtern n. Stem Cell Reports. 2022 Nov 8;17(11):2484-2500. doi: 10.1016/j.stemcr.2022.09.008. Epub 2022 Oct 20. Stem Cell Reports. 2022. PMID: 36270280 Free PMC article.
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH. Mansour AA, et al. Among authors: novershtern n. Nature. 2012 Aug 16;488(7411):409-13. doi: 10.1038/nature11272. Nature. 2012. PMID: 22801502
Deterministic direct reprogramming of somatic cells to pluripotency.
Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH. Rais Y, et al. Among authors: novershtern n. Nature. 2013 Oct 3;502(7469):65-70. doi: 10.1038/nature12587. Epub 2013 Sep 18. Nature. 2013. PMID: 24048479
Derivation of novel human ground state naive pluripotent stem cells.
Gafni O, Weinberger L, Mansour AA, Manor YS, Chomsky E, Ben-Yosef D, Kalma Y, Viukov S, Maza I, Zviran A, Rais Y, Shipony Z, Mukamel Z, Krupalnik V, Zerbib M, Geula S, Caspi I, Schneir D, Shwartz T, Gilad S, Amann-Zalcenstein D, Benjamin S, Amit I, Tanay A, Massarwa R, Novershtern N, Hanna JH. Gafni O, et al. Among authors: novershtern n. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30. Nature. 2013. PMID: 24172903
23 results