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A rapid intracellular enrichment of alkylating payload is essential for melphalan flufenamide potency and mechanism of action.
Westermark U, Diao Y, Fasth KJ, Färnegårdh M, Färnegårdh K, Hammer K, Lehmann F, Acs K, Svensson Gelius S. Westermark U, et al. Among authors: svensson gelius s. Biochem Biophys Res Commun. 2023 May 14;656:122-130. doi: 10.1016/j.bbrc.2023.03.009. Epub 2023 Mar 11. Biochem Biophys Res Commun. 2023. PMID: 37032581 Free article.
Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome.
Hendrikse NM, Sandegren A, Andersson T, Blomqvist J, Makower Å, Possner D, Su C, Thalén N, Tjernberg A, Westermark U, Rockberg J, Svensson Gelius S, Syrén PO, Nordling E. Hendrikse NM, et al. Among authors: svensson gelius s. iScience. 2021 Feb 6;24(3):102154. doi: 10.1016/j.isci.2021.102154. eCollection 2021 Mar 19. iScience. 2021. PMID: 33665572 Free PMC article.
Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice.
Gustavsson S, Ohlin Sjöström E, Tjernberg A, Janson J, Westermark U, Andersson T, Makower Å, Arnelöf E, Andersson G, Svartengren J, Ekholm C, Svensson Gelius S. Gustavsson S, et al. Among authors: svensson gelius s. Mol Genet Metab Rep. 2019 Sep 7;21:100510. doi: 10.1016/j.ymgmr.2019.100510. eCollection 2019 Dec. Mol Genet Metab Rep. 2019. PMID: 31528541 Free PMC article.
CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2.
Kalderén C, Stadler C, Forsgren M, Kvastad L, Johansson E, Sydow-Bäckman M, Svensson Gelius S. Kalderén C, et al. Among authors: svensson gelius s. Int Immunopharmacol. 2014 May;20(1):66-73. doi: 10.1016/j.intimp.2014.02.020. Epub 2014 Feb 26. Int Immunopharmacol. 2014. PMID: 24583146