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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
Neuron. 2023 Nov 15;111(22):3619-3633.e8. doi: 10.1016/j.neuron.2023.08.012. Epub 2023 Sep 8.
Neuron. 2023.
PMID: 37689059
Free article.
Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer's disease-related neuropathology in cell models.
Zhang S, Bai P, Lei D, Liang Y, Zhen S, Bakiasi G, Pang H, Choi SH, Wang C, Tanzi RE, Zhang C.
Zhang S, et al. Among authors: bakiasi g.
J Biol Chem. 2022 Apr;298(4):101794. doi: 10.1016/j.jbc.2022.101794. Epub 2022 Mar 3.
J Biol Chem. 2022.
PMID: 35248531
Free PMC article.
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Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology.
Mondal P, Bai P, Gomm A, Bakiasi G, Lin CJ, Wang Y, Choi SH, Tanzi RE, Wang C, Zhang C.
Mondal P, et al. Among authors: bakiasi g.
Adv Sci (Weinh). 2024 Jan;11(1):e2304545. doi: 10.1002/advs.202304545. Epub 2023 Nov 21.
Adv Sci (Weinh). 2024.
PMID: 37990786
Free PMC article.
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Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections.
Muffat J, Li Y, Omer A, Durbin A, Bosch I, Bakiasi G, Richards E, Meyer A, Gehrke L, Jaenisch R.
Muffat J, et al. Among authors: bakiasi g.
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7117-7122. doi: 10.1073/pnas.1719266115. Epub 2018 Jun 18.
Proc Natl Acad Sci U S A. 2018.
PMID: 29915057
Free PMC article.
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Efficient derivation of microglia-like cells from human pluripotent stem cells.
Muffat J, Li Y, Yuan B, Mitalipova M, Omer A, Corcoran S, Bakiasi G, Tsai LH, Aubourg P, Ransohoff RM, Jaenisch R.
Muffat J, et al. Among authors: bakiasi g.
Nat Med. 2016 Nov;22(11):1358-1367. doi: 10.1038/nm.4189. Epub 2016 Sep 26.
Nat Med. 2016.
PMID: 27668937
Free PMC article.
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