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203 results

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Page 1
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. Blaeschke F, et al. Among authors: to a. Cell. 2023 Sep 14;186(19):4216-4234.e33. doi: 10.1016/j.cell.2023.08.013. Cell. 2023. PMID: 37714135 Free article.
ModPoKI's modularity allowed us to generate an 10,000-member library of TF combinations. Non-viral KI of a combined BATF-TFAP4 polycistronic construct enhanced fitness. Overexpressed BATF and TFAP4 co-occupy and regulate key gene targets to reprogram T cell f …
ModPoKI's modularity allowed us to generate an 10,000-member library of TF combinations. Non-viral KI of a combined BATF-TFAP4 …
An evolved AAV variant enables efficient genetic engineering of murine T cells.
Nyberg WA, Ark J, To A, Clouden S, Reeder G, Muldoon JJ, Chung JY, Xie WH, Allain V, Steinhart Z, Chang C, Talbot A, Kim S, Rosales A, Havlik LP, Pimentel H, Asokan A, Eyquem J. Nyberg WA, et al. Among authors: to a. Cell. 2023 Jan 19;186(2):446-460.e19. doi: 10.1016/j.cell.2022.12.022. Epub 2023 Jan 12. Cell. 2023. PMID: 36638795 Free PMC article.
Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin efficiencies, but the tropism of current AAV serotypes restricts their use to human T cells employed in immunodeficient mouse models. To enable targeted knockins in murine T cell …
Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin efficiencies, but the tropism of current AAV serotyp …
Targeting monoamine oxidase A for T cell-based cancer immunotherapy.
Wang X, Li B, Kim YJ, Wang YC, Li Z, Yu J, Zeng S, Ma X, Choi IY, Di Biase S, Smith DJ, Zhou Y, Li YR, Ma F, Huang J, Clarke N, To A, Gong L, Pham AT, Moon H, Pellegrini M, Yang L. Wang X, et al. Among authors: to a. Sci Immunol. 2021 May 14;6(59):eabh2383. doi: 10.1126/sciimmunol.abh2383. Sci Immunol. 2021. PMID: 33990379
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Wang YC, Wang X, Yu J, Ma F, Li Z, Zhou Y, Zeng S, Ma X, Li YR, Neal A, Huang J, To A, Clarke N, Memarzadeh S, Pellegrini M, Yang L. Wang YC, et al. Among authors: to a. Nat Commun. 2021 Jun 10;12(1):3530. doi: 10.1038/s41467-021-23164-2. Nat Commun. 2021. PMID: 34112755 Free PMC article.
Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. ...Together, these data identify MAO-A as a critical regulator of TAMs and support repurposin …
Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment a …
Creatine uptake regulates CD8 T cell antitumor immunity.
Di Biase S, Ma X, Wang X, Yu J, Wang YC, Smith DJ, Zhou Y, Li Z, Kim YJ, Clarke N, To A, Yang L. Di Biase S, et al. Among authors: to a. J Exp Med. 2019 Dec 2;216(12):2869-2882. doi: 10.1084/jem.20182044. Epub 2019 Oct 18. J Exp Med. 2019. PMID: 31628186 Free PMC article.
When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell. ...We further demonstrat …
When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a C …
2024 CSANZ Position Statement on Indications, Assessment and Monitoring of Structural and Valvular Heart Disease With Transthoracic Echocardiography in Adults.
Chong A, Stanton T, Taylor A, Prior D, La Gerche A, Anderson B, Scalia G, Cooke J, Dahiya A, To A, Davis M, Mottram P, Moir S, Playford D, Mahadavan D, Thomas L, Wahi S. Chong A, et al. Among authors: to a. Heart Lung Circ. 2024 May 4:S1443-9506(24)00166-5. doi: 10.1016/j.hlc.2023.11.028. Online ahead of print. Heart Lung Circ. 2024. PMID: 38749800
Multivariate Bayesian Optimization of CoO Nanoparticles for CO2 Hydrogenation Catalysis.
Karadaghi LR, Williamson EM, To AT, Forsberg AP, Crans KD, Perkins CL, Hayden SC, LiBretto NJ, Baddour FG, Ruddy DA, Malmstadt N, Habas SE, Brutchey RL. Karadaghi LR, et al. Among authors: to at. J Am Chem Soc. 2024 May 22;146(20):14246-14259. doi: 10.1021/jacs.4c03789. Epub 2024 May 10. J Am Chem Soc. 2024. PMID: 38728108 Free PMC article.
203 results