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Short tandem repeats bind transcription factors to tune eukaryotic gene expression.
Science. 2023 Sep 22;381(6664):eadd1250. doi: 10.1126/science.add1250. Epub 2023 Sep 22.
Science. 2023.
PMID: 37733848
De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding.
Alexandari AM, Horton CA, Shrikumar A, Shah N, Li E, Weilert M, Pufall MA, Zeitlinger J, Fordyce PM, Kundaje A.
Alexandari AM, et al.
bioRxiv [Preprint]. 2023 May 11:2023.05.11.540401. doi: 10.1101/2023.05.11.540401.
bioRxiv. 2023.
PMID: 37214836
Free PMC article.
Preprint.
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Opportunities and obstacles for deep learning in biology and medicine.
Ching T, Himmelstein DS, Beaulieu-Jones BK, Kalinin AA, Do BT, Way GP, Ferrero E, Agapow PM, Zietz M, Hoffman MM, Xie W, Rosen GL, Lengerich BJ, Israeli J, Lanchantin J, Woloszynek S, Carpenter AE, Shrikumar A, Xu J, Cofer EM, Lavender CA, Turaga SC, Alexandari AM, Lu Z, Harris DJ, DeCaprio D, Qi Y, Kundaje A, Peng Y, Wiley LK, Segler MHS, Boca SM, Swamidass SJ, Huang A, Gitter A, Greene CS.
Ching T, et al. Among authors: alexandari am.
J R Soc Interface. 2018 Apr;15(141):20170387. doi: 10.1098/rsif.2017.0387.
J R Soc Interface. 2018.
PMID: 29618526
Free PMC article.
Review.
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