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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection.
Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J; Penn Medicine BioBank; Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. Painter MM, et al. Among authors: santos jjs. Nat Immunol. 2023 Oct;24(10):1711-1724. doi: 10.1038/s41590-023-01613-y. Epub 2023 Sep 21. Nat Immunol. 2023. PMID: 37735592
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.
Bolton MJ, Santos JJS, Arevalo CP, Griesman T, Watson M, Li SH, Bates P, Ramage H, Wilson PC, Hensley SE. Bolton MJ, et al. Among authors: santos jjs. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2216521120. doi: 10.1073/pnas.2216521120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603748 Free PMC article.
Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques.
Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ Jr, Maiello P, Scanga CA, Bowling JD, Bouwer AL, Duangkhae PA, Wiley CA, Flynn JL, Wang J, Cole KS, Perez DR, Reed DS, Barratt-Boyes SM. Wonderlich ER, et al. J Immunol. 2017 Feb 15;198(4):1616-1626. doi: 10.4049/jimmunol.1601770. Epub 2017 Jan 6. J Immunol. 2017. PMID: 28062701 Free PMC article.
Original Antigenic Sin: How Original? How Sinful?
Yewdell JW, Santos JJS. Yewdell JW, et al. Among authors: santos jjs. Cold Spring Harb Perspect Med. 2021 May 3;11(5):a038786. doi: 10.1101/cshperspect.a038786. Cold Spring Harb Perspect Med. 2021. PMID: 31964645 Free PMC article. Review.
Outflanking immunodominance to target subdominant broadly neutralizing epitopes.
Angeletti D, Kosik I, Santos JJS, Yewdell WT, Boudreau CM, Mallajosyula VVA, Mankowski MC, Chambers M, Prabhakaran M, Hickman HD, McDermott AB, Alter G, Chaudhuri J, Yewdell JW. Angeletti D, et al. Among authors: santos jjs. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13474-13479. doi: 10.1073/pnas.1816300116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213541 Free PMC article.
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