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Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.
Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Merrihew GE, Egertson JD, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, MacCoss MJ, Qian WJ, Marcinek DJ. Campbell MD, et al. Free Radic Biol Med. 2019 Apr;134:268-281. doi: 10.1016/j.freeradbiomed.2018.12.031. Epub 2018 Dec 28. Free Radic Biol Med. 2019. PMID: 30597195 Free PMC article.
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.
Whitson JA, Martín-Pérez M, Zhang T, Gaffrey MJ, Merrihew GE, Huang E, White CC, Kavanagh TJ, Qian WJ, Campbell MD, MacCoss MJ, Marcinek DJ, Villén J, Rabinovitch PS. Whitson JA, et al. Among authors: campbell md. Geroscience. 2021 Oct;43(5):2395-2412. doi: 10.1007/s11357-021-00447-6. Epub 2021 Sep 4. Geroscience. 2021. PMID: 34480713 Free PMC article.
Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice.
Campbell MD, Martín-Pérez M, Egertson JD, Gaffrey MJ, Wang L, Bammler T, Rabinovitch PS, MacCoss M, Qian WJ, Villen J, Marcinek D. Campbell MD, et al. Geroscience. 2022 Dec;44(6):2913-2924. doi: 10.1007/s11357-022-00679-0. Epub 2022 Nov 2. Geroscience. 2022. PMID: 36322234 Free PMC article.
The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ. Pharaoh G, et al. Among authors: campbell md. Geroscience. 2023 Dec;45(6):3529-3548. doi: 10.1007/s11357-023-00861-y. Epub 2023 Jul 18. Geroscience. 2023. PMID: 37462785 Free PMC article.
132 results