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Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.
Aguilar-Calvo P, Malik A, Sandoval DR, Barback C, Orrù CD, Standke HG, Thomas OR, Dwyer CA, Pizzo DP, Bapat J, Soldau K, Ogawa R, Riley MB, Nilsson KPR, Kraus A, Caughey B, Iliff JJ, Vera DR, Esko JD, Sigurdson CJ. Aguilar-Calvo P, et al. Among authors: malik a. PLoS Pathog. 2023 Sep 25;19(9):e1011487. doi: 10.1371/journal.ppat.1011487. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747931 Free PMC article.
Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration.
Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. Lawrence JA, et al. Among authors: malik a. J Neurosci. 2023 May 24;43(21):3970-3984. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub 2023 Apr 5. J Neurosci. 2023. PMID: 37019623 Free PMC article.
Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.
Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Ojeda-Juárez D, et al. Among authors: malik a. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. Neurobiol Dis. 2022. PMID: 35905927 Free PMC article.
In-silico and in-vitro studies revealed alpha-amyrin as a potent pnhibitor of TLR2 for the therapeutics of bacterial infection and sepsis.
Elgadir TA, El-Gamal B, Ellatif MA, Nasif KA, Omer S, Mohieldeen M, Patel AA, Amanullah M, Malik A, Mahfouz AA, Shaamash AH, Alsamghan AS. Elgadir TA, et al. Among authors: malik a. Cell Mol Biol (Noisy-le-grand). 2024 Jun 5;70(6):97-107. doi: 10.14715/cmb/2024.70.6.16. Cell Mol Biol (Noisy-le-grand). 2024. PMID: 38836674
Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050.
GBD 2019 MSK in Adolescents Collaborators. Electronic address: dongze_wu@163.com; GBD 2019 MSK in Adolescents Collaborators. GBD 2019 MSK in Adolescents Collaborators. Electronic address: dongze_wu@163.com, et al. Med. 2024 May 30:S2666-6340(24)00179-X. doi: 10.1016/j.medj.2024.04.009. Online ahead of print. Med. 2024. PMID: 38834074
5,010 results