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Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme.
Dulchavsky M, Mitra R, Wu K, Li J, Boer K, Liu X, Zhang Z, Vasquez C, Clark CT, Funckes K, Shankar K, Bonnet-Zahedi S, Siddiq M, Sepulveda Y, Suhandynata RT, Momper JD, Calabrese AN, George O, Stull F, Bardwell JCA. Dulchavsky M, et al. Among authors: george o. Nat Chem Biol. 2023 Nov;19(11):1406-1414. doi: 10.1038/s41589-023-01426-y. Epub 2023 Sep 28. Nat Chem Biol. 2023. PMID: 37770699 Free PMC article.
Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.
Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. Kimbrough A, et al. Among authors: george o. Psychopharmacology (Berl). 2020 May;237(5):1545-1555. doi: 10.1007/s00213-020-05479-y. Epub 2020 Feb 29. Psychopharmacology (Berl). 2020. PMID: 32114633 Free PMC article.
Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats.
Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. Smith LC, et al. Among authors: george o. Psychopharmacology (Berl). 2021 Aug;238(8):2201-2211. doi: 10.1007/s00213-021-05845-4. Epub 2021 Apr 28. Psychopharmacology (Berl). 2021. PMID: 33909102 Free PMC article.
An enzymatic advance in nicotine cessation therapy.
Xue S , Kallupi M , Zhou B , Smith LC , Miranda PO , George O , Janda KD . Xue S , et al. Among authors: george o. Chem Commun (Camb). 2018 Feb 13;54(14):1686-1689. doi: 10.1039/c7cc09134f. Chem Commun (Camb). 2018. PMID: 29308799 Free PMC article.
Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use.
Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. Smith LC, et al. Among authors: george o. Neuropsychopharmacology. 2020 Oct;45(11):1909-1919. doi: 10.1038/s41386-020-0734-8. Epub 2020 Jun 16. Neuropsychopharmacology. 2020. PMID: 32544927 Free PMC article.
203 results