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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.
Nat Commun. 2023 Sep 30;14(1):6119. doi: 10.1038/s41467-023-41860-z.
Nat Commun. 2023.
PMID: 37777536
Free PMC article.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL.
Mattis KK, et al. Among authors: thaman s.
Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12.
Diabetologia. 2023.
PMID: 36633628
Free PMC article.
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Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists.
Umapathysivam MM, Araldi E, Hastoy B, Dawed AY, Vatandaslar H, Sengupta S, Kaufmann A, Thomsen S, Hartmann B, Jonsson AE, Kabakci H, Thaman S, Grarup N, Have CT, Færch K, Gjesing AP, Nawaz S, Cheeseman J, Neville MJ, Pedersen O, Walker M, Jennison C, Hattersley AT, Hansen T, Karpe F, Holst JJ, Jones AG, Ristow M, McCarthy MI, Pearson ER, Stoffel M, Gloyn AL.
Umapathysivam MM, et al. Among authors: thaman s.
medRxiv [Preprint]. 2023 Apr 12:2023.04.07.23288197. doi: 10.1101/2023.04.07.23288197.
medRxiv. 2023.
PMID: 37090505
Free PMC article.
Preprint.
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