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The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Baumgartner CK, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel KM, Olander KE, Davis TGR, McGuire KA, Halvorsen GT, Avila OI, Patel CH, Kim SY, Kammula AV, Muscato AJ, Halliwill K, Geda P, Klinge KL, Xiong Z, Duggan R, Mu L, Yeary MD, Patti JC, Balon TM, Mathew R, Backus C, Kennedy DE, Chen A, Longenecker K, Klahn JT, Hrusch CL, Krishnan N, Hutchins CW, Dunning JP, Bulic M, Tiwari P, Colvin KJ, Chuong CL, Kohnle IC, Rees MG, Boghossian A, Ronan M, Roth JA, Wu MJ, Suermondt JSMT, Knudsen NH, Cheruiyot CK, Sen DR, Griffin GK, Golub TR, El-Bardeesy N, Decker JH, Yang Y, Guffroy M, Fossey S, Trusk P, Sun IM, Liu Y, Qiu W, Sun Q, Paddock MN, Farney EP, Matulenko MA, Beauregard C, Frost JM, Yates KB, Kym PR, Manguso RT. Baumgartner CK, et al. Among authors: kennedy de. Nature. 2023 Oct;622(7984):850-862. doi: 10.1038/s41586-023-06575-7. Epub 2023 Oct 4. Nature. 2023. PMID: 37794185 Free PMC article.
The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.
Lee V, Rodriguez DM, Ganci NK, Zeng S, Ai J, Chao JL, Walker MT, Miller CH, Klawon DEJ, Schoenbach MH, Kennedy DE, Maienschein-Cline M, Socci ND, Clark MR, Savage PA. Lee V, et al. Among authors: kennedy de. Nat Immunol. 2023 Mar;24(3):487-500. doi: 10.1038/s41590-023-01425-0. Epub 2023 Feb 9. Nat Immunol. 2023. PMID: 36759711 Free PMC article.
Quantifying in situ adaptive immune cell cognate interactions in humans.
Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Liarski VM, et al. Nat Immunol. 2019 Apr;20(4):503-513. doi: 10.1038/s41590-019-0315-3. Epub 2019 Feb 18. Nat Immunol. 2019. PMID: 30778242 Free PMC article.
PI3Kδ: Too much of a good thing.
Kennedy DE, Clark MR. Kennedy DE, et al. Nat Immunol. 2018 Sep;19(9):910-911. doi: 10.1038/s41590-018-0183-2. Nat Immunol. 2018. PMID: 30127436 No abstract available.
BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.
Mandal M, Maienschein-Cline M, Maffucci P, Veselits M, Kennedy DE, McLean KC, Okoreeh MK, Karki S, Cunningham-Rundles C, Clark MR. Mandal M, et al. Among authors: kennedy de. Nat Commun. 2018 Sep 24;9(1):3888. doi: 10.1038/s41467-018-06165-6. Nat Commun. 2018. PMID: 30250168 Free PMC article.
Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing.
Okoreeh MK, Kennedy DE, Emmanuel AO, Veselits M, Moshin A, Ladd RH, Erickson S, McLean KC, Madrigal B, Nemazee D, Maienschein-Cline M, Mandal M, Clark MR. Okoreeh MK, et al. Among authors: kennedy de. Sci Immunol. 2022 Aug 5;7(74):eabm1664. doi: 10.1126/sciimmunol.abm1664. Epub 2022 Aug 5. Sci Immunol. 2022. PMID: 35930652 Free PMC article.
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