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Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species.
Srinivas N, Rosen EP, Gilliland WM Jr, Kovarova M, Remling-Mulder L, De La Cruz G, White N, Adamson L, Schauer AP, Sykes C, Luciw P, Garcia JV, Akkina R, Kashuba ADM. Srinivas N, et al. Among authors: de la cruz g. Xenobiotica. 2019 Oct;49(10):1192-1201. doi: 10.1080/00498254.2018.1539278. Epub 2018 Dec 17. Xenobiotica. 2019. PMID: 30346892 Free PMC article.
Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species.
Thompson CG, Rosen EP, Prince HMA, White N, Sykes C, de la Cruz G, Mathews M, Deleage C, Estes JD, Charlins P, Mulder LR, Kovarova M, Adamson L, Arora S, Dellon ES, Peery AF, Shaheen NJ, Gay C, Muddiman DC, Akkina R, Garcia JV, Luciw P, Kashuba ADM. Thompson CG, et al. Among authors: de la cruz g. Sci Transl Med. 2019 Jul 3;11(499):eaap8758. doi: 10.1126/scitranslmed.aap8758. Sci Transl Med. 2019. PMID: 31270274 Free PMC article. Clinical Trial.
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Leist SR, De la Cruz G, West A, Atochina-Vasserman EN, Lindesmith LC, Pardi N, Parks R, Barr M, Li D, Yount B, Saunders KO, Weissman D, Haynes BF, Montgomery SA, Baric RS. Martinez DR, et al. Among authors: de la cruz g. bioRxiv [Preprint]. 2021 May 11:2021.03.11.434872. doi: 10.1101/2021.03.11.434872. bioRxiv. 2021. PMID: 33758837 Free PMC article. Updated. Preprint.
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Collagen in the Mesenteric Lymph Nodes of Nonhuman Primates.
Scholz EMB, Mwangi JN, De la Cruz G, Nekorchuk M, Chan CN, Busman-Sahay K, Adamson L, Luciw P, Fedoriw Y, Estes JD, Rosen EP, Kashuba ADM. Scholz EMB, et al. Among authors: de la cruz g. Antimicrob Agents Chemother. 2021 May 18;65(6):e00019-21. doi: 10.1128/AAC.00019-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33782003 Free PMC article.
A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.
Martinez DR, Schaefer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Manne K, Mansouri K, Edwards RJ, Yount B, Anasti K, Montgomery SA, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam M, Sempowski GD, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS. Martinez DR, et al. Among authors: de la cruz g. bioRxiv [Preprint]. 2021 Apr 28:2021.04.27.441655. doi: 10.1101/2021.04.27.441655. bioRxiv. 2021. PMID: 33948590 Free PMC article. Preprint.
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Leist SR, De la Cruz G, West A, Atochina-Vasserman EN, Lindesmith LC, Pardi N, Parks R, Barr M, Li D, Yount B, Saunders KO, Weissman D, Haynes BF, Montgomery SA, Baric RS. Martinez DR, et al. Among authors: de la cruz g. Science. 2021 Aug 27;373(6558):991-998. doi: 10.1126/science.abi4506. Epub 2021 Jun 22. Science. 2021. PMID: 34214046 Free PMC article.
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates.
Devanathan AS, White NR, Desyaterik Y, De la Cruz G, Nekorchuk M, Terry M, Busman-Sahay K, Adamson L, Luciw P, Fedoriw Y, Estes JD, Rosen EP, Kashuba ADM. Devanathan AS, et al. Among authors: de la cruz g. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0060922. doi: 10.1128/aac.00609-22. Epub 2022 Jul 20. Antimicrob Agents Chemother. 2022. PMID: 35856680 Free PMC article.
Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection.
Young IC, Massud I, Cottrell ML, Shrivastava R, Maturavongsadit P, Prasher A, Wong-Sam A, Dinh C, Edwards T, Mrotz V, Mitchell J, Seixas JN, Pallerla A, Thorson A, Schauer A, Sykes C, De la Cruz G, Montgomery SA, Kashuba ADM, Heneine W, Dobard CW, Kovarova M, Garcia JV, García-Lerma JG, Benhabbour SR. Young IC, et al. Among authors: de la cruz g. Nat Commun. 2023 Feb 9;14(1):708. doi: 10.1038/s41467-023-36330-5. Nat Commun. 2023. PMID: 36759645 Free PMC article.
Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.
Martinez DR, Moreira FR, Zweigart MR, Gully KL, De la Cruz G, Brown AJ, Adams LE, Catanzaro N, Yount B, Baric TJ, Mallory ML, Conrad H, May SR, Dong S, Scobey DT, Montgomery SA, Perry J, Babusis D, Barrett KT, Nguyen AH, Nguyen AQ, Kalla R, Bannister R, Bilello JP, Feng JY, Cihlar T, Baric RS, Mackman RL, Schäfer A, Sheahan TP. Martinez DR, et al. Among authors: de la cruz g. bioRxiv [Preprint]. 2023 Jun 28:2023.06.27.546784. doi: 10.1101/2023.06.27.546784. bioRxiv. 2023. PMID: 37425890 Free PMC article. Preprint.
76 results