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Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs.
van der Velden S, van Osch TLJ, Seghier A, Bentlage AEH, Mok JY, Geerdes DM, van Esch WJE, Pouw RB, Brouwer MC, Jongerius I, de Haas M, Porcelijn L, van der Schoot CE, Vidarsson G, Kapur R. van der Velden S, et al. Among authors: pouw rb. Blood. 2024 Jan 4;143(1):79-91. doi: 10.1182/blood.2023020484. Blood. 2024. PMID: 37801721
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation.
de Boer EC, Thielen AJ, Langereis JD, Kamp A, Brouwer MC, Oskam N, Jongsma ML, Baral AJ, Spaapen RM, Zeerleder S, Vidarsson G, Rispens T, Wouters D, Pouw RB, Jongerius I. de Boer EC, et al. Among authors: pouw rb. Clin Transl Immunology. 2023 Jan 27;12(1):e1436. doi: 10.1002/cti2.1436. eCollection 2023. Clin Transl Immunology. 2023. PMID: 36721662 Free PMC article.
No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice.
Hibender S, Li S, Postma AV, Hoogeland ME, Klaver D, Pouw RB, Niessen HW, Driessen AH, Koolbergen DR, de Vries CJ, Baars MJ, Houweling AC, Krijnen PA, de Waard V. Hibender S, et al. Among authors: pouw rb. Vasc Biol. 2022 Nov 30;4(1):40-49. doi: 10.1530/VB-22-0016. Print 2022 Nov 1. Vasc Biol. 2022. PMID: 36279189 Free PMC article.
Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations.
Kumar V, Pouw RB, Autio MI, Sagmeister MG, Phua ZY, Borghini L, Wright VJ, Hoggart C, Pan B, Tan AKY, Binder A, Brouwer MC, Pinnock E, De Groot R, Hazelzet J, Emonts M, Van Der Flier M, Reiter K, Nöthen MM, Hoffmann P; EUCLIDS consortium; Schlapbach LJ, Bellos E, Anderson S, Secka F, Martinón-Torres F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Zenz W, Wouters D, Ang LT, Hibberd ML, Levin M, Kuijpers TW, Davila S. Kumar V, et al. Among authors: pouw rb. Am J Hum Genet. 2022 Sep 1;109(9):1680-1691. doi: 10.1016/j.ajhg.2022.08.001. Epub 2022 Aug 24. Am J Hum Genet. 2022. PMID: 36007525 Free PMC article.
Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis.
van Beek AE, Pouw RB, Wright VJ, Sallah N, Inwald D, Hoggart C, Brouwer MC, Galassini R, Thomas J, Calvo-Bado L, Fink CG, Jongerius I, Hibberd M, Wouters D, Levin M, Kuijpers TW. van Beek AE, et al. Among authors: pouw rb. Front Immunol. 2022 May 26;13:876776. doi: 10.3389/fimmu.2022.876776. eCollection 2022. Front Immunol. 2022. PMID: 35720329 Free PMC article.
Complement & disease: out of the shadow into the spotlight.
Ricklin D, Pouw RB. Ricklin D, et al. Among authors: pouw rb. Semin Immunopathol. 2021 Dec;43(6):755-756. doi: 10.1007/s00281-021-00897-2. Semin Immunopathol. 2021. PMID: 34820685 Free PMC article. No abstract available.
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