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Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial.
Sobieszczyk ME, Mannheimer S, Paez CA, Yu C, Gamble T, Theodore DA, Chege W, Yacovone M, Hanscom B, Heptinstall J, Seaton KE, Zhang L, Miner MD, Eaton A, Weiner JA, Mayer K, Kalams S, Stephenson K, Julg B, Caskey M, Nussenzweig M, Gama L, Barouch DH, Ackerman ME, Tomaras GD, Huang Y, Montefiori D; HVTN 130/HPTN 089 Study Team. Sobieszczyk ME, et al. Among authors: nussenzweig m. Lancet HIV. 2023 Oct;10(10):e653-e662. doi: 10.1016/S2352-3018(23)00140-6. Lancet HIV. 2023. PMID: 37802566 Clinical Trial.
Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
Greaney AJ, Starr TN, Barnes CO, Weisblum Y, Schmidt F, Caskey M, Gaebler C, Cho A, Agudelo M, Finkin S, Wang Z, Poston D, Muecksch F, Hatziioannou T, Bieniasz PD, Robbiani DF, Nussenzweig MC, Bjorkman PJ, Bloom JD. Greaney AJ, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2021 Mar 18:2021.03.17.435863. doi: 10.1101/2021.03.17.435863. bioRxiv. 2021. PMID: 33758856 Free PMC article. Updated. Preprint.
Plasma neutralization properties of the SARS-CoV-2 Omicron variant.
Schmidt F, Muecksch F, Weisblum Y, Da Silva J, Bednarski E, Cho A, Wang Z, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Schmidt F, et al. Among authors: nussenzweig mc. medRxiv [Preprint]. 2021 Dec 13:2021.12.12.21267646. doi: 10.1101/2021.12.12.21267646. medRxiv. 2021. PMID: 34931199 Free PMC article. Updated. Preprint.
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.
Witte L, Baharani V, Schmidt F, Wang Z, Cho A, Raspe R, Guzman-Cardozo MC, Muecksch F, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Witte L, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Aug 19:2022.08.17.504313. doi: 10.1101/2022.08.17.504313. bioRxiv. 2022. PMID: 36032981 Free PMC article. Updated. Preprint.
HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. Prévost J, et al. Among authors: nussenzweig mc. Cell Rep. 2022 Nov 8;41(6):111624. doi: 10.1016/j.celrep.2022.111624. Cell Rep. 2022. PMID: 36351384 Free PMC article.
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity.
Zhang F, Schmidt F, Muecksch F, Wang Z, Gazumyan A, Nussenzweig MC, Gaebler C, Caskey M, Hatziioannou T, Bieniasz PD. Zhang F, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2023 Jun 30:2023.06.30.547241. doi: 10.1101/2023.06.30.547241. bioRxiv. 2023. PMID: 37425700 Free PMC article. Updated. Preprint.
Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Subvariant Neutralization Following a Primary Vaccine Series of NVX-CoV2373 and BNT162b2 Monovalent Booster Vaccine.
Babu TM, Shen X, McClelland RS, Wang Z, Selke S, Wilkens C, Hauge KA, McClurkan CL, Goecker E, Laing KJ, Koelle DM, Greninger AL, Nussenzweig MC, Montefiori DC, Corey L, Wald A. Babu TM, et al. Among authors: nussenzweig mc. Open Forum Infect Dis. 2024 Jan 3;11(2):ofad673. doi: 10.1093/ofid/ofad673. eCollection 2024 Feb. Open Forum Infect Dis. 2024. PMID: 38379566 Free PMC article.
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection. Abdel-Mohsen M, et al. Among authors: nussenzweig mc. Nat Med. 2020 Sep;26(9):1339-1350. doi: 10.1038/s41591-020-1022-1. Epub 2020 Sep 7. Nat Med. 2020. PMID: 32895573 Free PMC article. Review.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
West AP Jr, Wertheim JO, Wang JC, Vasylyeva TI, Havens JL, Chowdhury MA, Gonzalez E, Fang CE, Di Lonardo SS, Hughes S, Rakeman JL, Lee HH, Barnes CO, Gnanapragasam PNP, Yang Z, Gaebler C, Caskey M, Nussenzweig MC, Keeffe JR, Bjorkman PJ. West AP Jr, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2021 Apr 22:2021.02.14.431043. doi: 10.1101/2021.02.14.431043. bioRxiv. 2021. PMID: 33907745 Free PMC article. Updated. Preprint.
Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins.
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Tanfous TB, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC. Wang Z, et al. Among authors: nussenzweig mc. bioRxiv [Preprint]. 2022 Feb 1:2022.02.01.478695. doi: 10.1101/2022.02.01.478695. bioRxiv. 2022. PMID: 35132412 Free PMC article. Updated. Preprint.
512 results