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Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25-6981, increases glutamate neurotransmission and induces antidepressant-like effects.
Doan J, Defaix C, Mendez-David I, Gardier AM, Colle R, Corruble E, McGowan JC, David DJ, Guilloux JP, Tritschler L. Doan J, et al. Among authors: mendez david i. Fundam Clin Pharmacol. 2023 Dec;37(6):1119-1128. doi: 10.1111/fcp.12917. Epub 2023 Jun 1. Fundam Clin Pharmacol. 2023. PMID: 37161789
Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity.
Nguyen TML, Defaix C, Mendez-David I, Tritschler L, Etting I, Alvarez JC, Choucha W, Colle R, Corruble E, David DJ, Gardier AM. Nguyen TML, et al. Among authors: mendez david i. Neuropharmacology. 2023 Mar 1;225:109357. doi: 10.1016/j.neuropharm.2022.109357. Epub 2022 Nov 30. Neuropharmacology. 2023. PMID: 36462636
The GG genotype of the serotonin 4 receptor genetic polymorphism, rs1345697, is associated with lower remission rates after antidepressant treatment: Findings from the METADAP cohort.
Poinsignon V, Colle R, Asmar KE, Mendez-David I, David DJ, Ait Tayeb AEK, Chappell K, Gressier F, Herrero H, Fève B, Becquemont L, Corruble E, Verstuyft C. Poinsignon V, et al. Among authors: mendez david i. J Affect Disord. 2022 Feb 15;299:335-343. doi: 10.1016/j.jad.2021.12.012. Epub 2021 Dec 11. J Affect Disord. 2022. PMID: 34906639
Reviving through human hippocampal newborn neurons.
Mendez-David I, Schofield R, Tritschler L, Colle R, Guilloux JP, Gardier AM, Corruble E, Hen R, David DJ. Mendez-David I, et al. Encephale. 2022 Apr;48(2):179-187. doi: 10.1016/j.encep.2021.09.001. Epub 2021 Oct 11. Encephale. 2022. PMID: 34649711 Review.
Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.
Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, Cooper TB, Shah A, Brachman RA, Mendez-David I, David DJ, Gardier AM, Landry DW, Denny CA. Chen BK, et al. Among authors: mendez david i. Neuropsychopharmacology. 2020 Aug;45(9):1545-1556. doi: 10.1038/s41386-020-0714-z. Epub 2020 May 17. Neuropsychopharmacology. 2020. PMID: 32417852 Free PMC article.
28 results