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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease.
Nambulli S, Escriou N, Rennick LJ, Demers MJ, Tilston-Lunel NL, McElroy AK, Barbeau DJ, Crossland NA, Hoehl RM, Schrauf S, White AG, Borish HJ, Tomko JA, Frye LJ, Scanga CA, Flynn JL, Martin A, Gerke C, Hartman AL, Duprex WP. Nambulli S, et al. Among authors: borish hj. J Virol. 2024 May 14;98(5):e0176223. doi: 10.1128/jvi.01762-23. Epub 2024 Apr 2. J Virol. 2024. PMID: 38563762 Free article.
Author Correction: Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, Bucsan AN, Darrah PA, Seder RA, Roederer M, Lin PL, Flynn JL, O'Connor SL, Scanga CA. Larson EC, et al. Among authors: borish hj. Nat Microbiol. 2024 Feb 14. doi: 10.1038/s41564-024-01631-y. Online ahead of print. Nat Microbiol. 2024. PMID: 38355766 No abstract available.
CD4+ T cells are homeostatic regulators during Mtb reinfection.
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang D, Rosenberg JM, Klein EC, Gideon HP, Floyd-O'Sullivan R, Berger B, Scanga CA, Lin PL, Fortune SM, Shalek AK, Flynn JL. Bromley JD, et al. Among authors: borish hj. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572669. doi: 10.1101/2023.12.20.572669. bioRxiv. 2023. PMID: 38187598 Free PMC article. Preprint.
A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques.
Smith AA, Su H, Wallach J, Liu Y, Maiello P, Borish HJ, Winchell C, Simonson AW, Lin PL, Rodgers M, Fillmore D, Sakal J, Lin K, Schnappinger D, Ehrt S, Flynn JL. Smith AA, et al. Among authors: borish hj. bioRxiv [Preprint]. 2023 Nov 22:2023.11.22.568105. doi: 10.1101/2023.11.22.568105. bioRxiv. 2023. PMID: 38045242 Free PMC article. Preprint.
Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, Bucsan AN, Darrah PA, Seder RA, Roederer M, Lin PL, Flynn JL, O'Connor SL, Scanga CA. Larson EC, et al. Among authors: borish hj. Nat Microbiol. 2023 Nov;8(11):2080-2092. doi: 10.1038/s41564-023-01503-x. Epub 2023 Oct 9. Nat Microbiol. 2023. PMID: 37814073 Free PMC article.
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.
Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, Chishti HB, Tomko J, Frye LJ, Fillmore D, Kracinovsky K, Sakal J, Scanga CA, Lin PL, Dartois V, Linderman JJ, Flynn JL, Kirschner DE. Budak M, et al. Among authors: borish hj. PLoS Comput Biol. 2023 Jun 15;19(6):e1010823. doi: 10.1371/journal.pcbi.1010823. eCollection 2023 Jun. PLoS Comput Biol. 2023. PMID: 37319311 Free PMC article.
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques.
Darrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M. Darrah PA, et al. Among authors: borish hj. Cell Host Microbe. 2023 Jun 14;31(6):962-977.e8. doi: 10.1016/j.chom.2023.05.006. Epub 2023 Jun 1. Cell Host Microbe. 2023. PMID: 37267955
Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis.
Larson EC, Ellis-Connell AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Ameel CL, Jauro S, Tomko JA, Kracinovsky KB, Maiello P, Borish HJ, White AG, Klein E, Bucsan AN, Darrah PA, Seder RA, Roederer M, Lin PL, Flynn JL, O'Connor SL, Scanga CA. Larson EC, et al. Among authors: borish hj. Res Sq [Preprint]. 2023 Apr 17:rs.3.rs-2802306. doi: 10.21203/rs.3.rs-2802306/v1. Res Sq. 2023. PMID: 37090620 Free PMC article. Updated. Preprint.
Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques.
Larson EC, Ellis AL, Rodgers MA, Gubernat AK, Gleim JL, Moriarty RV, Balgeman AJ, Menezes YK, Ameel CL, Fillmore DJ, Pergalske SM, Juno JA, Maiello P, White AG, Borish HJ, Godfrey DI, Kent SJ, Ndhlovu LC, O'Connor SL, Scanga CA. Larson EC, et al. Among authors: borish hj. Infect Immun. 2023 May 16;91(5):e0055822. doi: 10.1128/iai.00558-22. Epub 2023 Apr 11. Infect Immun. 2023. PMID: 37039653 Free PMC article.
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