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Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun. 2023 Oct 10;14(1):6345. doi: 10.1038/s41467-023-41894-3.
Nat Commun. 2023.
PMID: 37816714
Free PMC article.
Mechanistic and Structural Features of PROTAC Ternary Complexes.
Casement R, Bond A, Craigon C, Ciulli A.
Casement R, et al.
Methods Mol Biol. 2021;2365:79-113. doi: 10.1007/978-1-0716-1665-9_5.
Methods Mol Biol. 2021.
PMID: 34432240
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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Hanzl A, Casement R, Imrichova H, Hughes SJ, Barone E, Testa A, Bauer S, Wright J, Brand M, Ciulli A, Winter GE.
Hanzl A, et al. Among authors: casement r.
Nat Chem Biol. 2023 Mar;19(3):323-333. doi: 10.1038/s41589-022-01177-2. Epub 2022 Nov 3.
Nat Chem Biol. 2023.
PMID: 36329119
Free PMC article.
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Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers.
Vu LP, Diehl CJ, Casement R, Bond AG, Steinebach C, Strašek N, Bricelj A, Perdih A, Schnakenburg G, Sosič I, Ciulli A, Gütschow M.
Vu LP, et al. Among authors: casement r.
J Med Chem. 2023 Sep 28;66(18):12776-12811. doi: 10.1021/acs.jmedchem.3c00434. Epub 2023 Sep 14.
J Med Chem. 2023.
PMID: 37708384
Free PMC article.
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Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A.
Hsia O, et al. Among authors: casement r.
Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21.
Nature. 2024.
PMID: 38383787
Free PMC article.
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Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii.
Shubitz LF, Dial SM, Perrill R, Casement R, Galgiani JN.
Shubitz LF, et al. Among authors: casement r.
Infect Immun. 2008 Dec;76(12):5553-64. doi: 10.1128/IAI.00885-08. Epub 2008 Oct 13.
Infect Immun. 2008.
PMID: 18852250
Free PMC article.
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History of the Mater Infirmorum Hospital.
Casement RS.
Casement RS.
Ulster Med J. 1969 Winter;38(1):62-75.
Ulster Med J. 1969.
PMID: 4896222
Free PMC article.
No abstract available.
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