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Ligand entry pathways control the chemical space recognized by GPR183.
Kjær VMS, Stępniewski TM, Medel-Lacruz B, Reinmuth L, Ciba M, Rexen Ulven E, Bonomi M, Selent J, Rosenkilde MM. Kjær VMS, et al. Among authors: rosenkilde mm. Chem Sci. 2023 Sep 25;14(39):10671-10683. doi: 10.1039/d2sc05962b. eCollection 2023 Oct 11. Chem Sci. 2023. PMID: 37829039 Free PMC article.
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.
Sommer ME, Selent J, Carlsson J, De Graaf C, Gloriam DE, Keseru GM, Kosloff M, Mordalski S, Rizk A, Rosenkilde MM, Sotelo E, Tiemann JKS, Tobin A, Vardjan N, Waldhoer M, Kolb P. Sommer ME, et al. Among authors: rosenkilde mm. ACS Pharmacol Transl Sci. 2020 Mar 31;3(2):361-370. doi: 10.1021/acsptsci.0c00024. eCollection 2020 Apr 10. ACS Pharmacol Transl Sci. 2020. PMID: 32296774 Free PMC article.
GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.
Barington L, Christensen LVV, Pedersen KK, Niss Arfelt K, Roumain M, Jensen KHR, Kjær VMS, Daugvilaite V, Kearney JF, Christensen JP, Hjortø GM, Muccioli GG, Holst PJ, Rosenkilde MM. Barington L, et al. Among authors: rosenkilde mm. Cells. 2022 Jan 31;11(3):494. doi: 10.3390/cells11030494. Cells. 2022. PMID: 35159303 Free PMC article.
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
Kjær VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jørgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjortø GM, Moo EV, Selent J, Rosenkilde MM. Kjær VMS, et al. Among authors: rosenkilde mm. Sci Signal. 2023 Apr 4;16(779):eabl4283. doi: 10.1126/scisignal.abl4283. Epub 2023 Apr 4. Sci Signal. 2023. PMID: 37014928
Discovery of GPR183 Agonists Based on an Antagonist Scaffold.
Kjaer VMS, Ieremias L, Daugvilaite V, Lückmann M, Frimurer TM, Ulven T, Rosenkilde MM, Våbenø J. Kjaer VMS, et al. Among authors: rosenkilde mm. ChemMedChem. 2021 Sep 6;16(17):2623-2627. doi: 10.1002/cmdc.202100301. Epub 2021 Aug 3. ChemMedChem. 2021. PMID: 34270165 Free PMC article.
Glycine: a long-sought novel ligand for GPR158.
Rosenkilde MM, Mathiesen JM. Rosenkilde MM, et al. Trends Pharmacol Sci. 2023 Aug;44(8):489-491. doi: 10.1016/j.tips.2023.05.004. Epub 2023 Jun 13. Trends Pharmacol Sci. 2023. PMID: 37321907
267 results