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Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data.
Pardiñas AF, Kappel DB, Roberts M, Tipple F, Shitomi-Jones LM, King A, Jansen J, Helthuis M, Owen MJ, O'Donovan MC, Walters JTR. Pardiñas AF, et al. Lancet Psychiatry. 2023 Mar;10(3):209-219. doi: 10.1016/S2215-0366(23)00002-0. Lancet Psychiatry. 2023. PMID: 36804072 Free PMC article.
A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.
Legge SE, Pardiñas AF, Helthuis M, Jansen JA, Jollie K, Knapper S, MacCabe JH, Rujescu D, Collier DA, O'Donovan MC, Owen MJ, Walters JTR. Legge SE, et al. Among authors: pardinas af. Mol Psychiatry. 2019 Mar;24(3):328-337. doi: 10.1038/s41380-018-0335-7. Epub 2019 Jan 15. Mol Psychiatry. 2019. PMID: 30647433
Clinical indicators of treatment-resistant psychosis.
Legge SE, Dennison CA, Pardiñas AF, Rees E, Lynham AJ, Hopkins L, Bates L, Kirov G, Owen MJ, O'Donovan MC, Walters JTR. Legge SE, et al. Among authors: pardinas af. Br J Psychiatry. 2020 May;216(5):259-266. doi: 10.1192/bjp.2019.120. Br J Psychiatry. 2020. PMID: 31155017
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia.
Richards AL, Pardiñas AF, Frizzati A, Tansey KE, Lynham AJ, Holmans P, Legge SE, Savage JE, Agartz I, Andreassen OA, Blokland GAM, Corvin A, Cosgrove D, Degenhardt F, Djurovic S, Espeseth T, Ferraro L, Gayer-Anderson C, Giegling I, van Haren NE, Hartmann AM, Hubert JJ, Jönsson EG, Konte B, Lennertz L, Olde Loohuis LM, Melle I, Morgan C, Morris DW, Murray RM, Nyman H, Ophoff RA; GROUP Investigators; van Os J; EUGEI WP2 Group; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Petryshen TL, Quattrone D, Rietschel M, Rujescu D, Rutten BPF, Streit F, Strohmaier J, Sullivan PF, Sundet K, Wagner M, Escott-Price V, Owen MJ, Donohoe G, O'Donovan MC, Walters JTR. Richards AL, et al. Among authors: pardinas af. Schizophr Bull. 2020 Feb 26;46(2):336-344. doi: 10.1093/schbul/sbz061. Schizophr Bull. 2020. PMID: 31206164 Free PMC article.
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.
Konte B, Walters JTR, Rujescu D, Legge SE, Pardiñas AF, Cohen D, Pirmohamed M, Tiihonen J, Hartmann AM, Bogers JP, van der Weide J, van der Weide K, Putkonen A, Repo-Tiihonen E, Hallikainen T, Silva E, Ingimarsson O, Sigurdsson E, Kennedy JL, Sullivan PF, Rietschel M, Breen G, Stefansson H, Stefansson K, Collier DA, O'Donovan MC, Giegling I. Konte B, et al. Among authors: pardinas af. Transl Psychiatry. 2021 Apr 12;11(1):214. doi: 10.1038/s41398-021-01322-w. Transl Psychiatry. 2021. PMID: 33846298 Free PMC article.
88 results