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Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count.
Schizophrenia (Heidelb). 2023 Oct 18;9(1):74. doi: 10.1038/s41537-023-00404-6.
Schizophrenia (Heidelb). 2023.
PMID: 37853043
Free PMC article.
Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores.
Kappel DB, Legge SE, Hubbard L, Willcocks IR, O'Connell KS, Smith RL, Molden E, Andreassen OA, King A, Jansen J, Helthuis M, Owen MJ, O'Donovan MC, Walters JTR, Pardiñas AF.
Kappel DB, et al. Among authors: willcocks ir.
Biol Psychiatry. 2023 Jan 15;93(2):149-156. doi: 10.1016/j.biopsych.2022.07.014. Epub 2022 Aug 5.
Biol Psychiatry. 2023.
PMID: 36244804
Free PMC article.
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Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
Pardiñas AF, Smart SE, Willcocks IR, Holmans PA, Dennison CA, Lynham AJ, Legge SE, Baune BT, Bigdeli TB, Cairns MJ, Corvin A, Fanous AH, Frank J, Kelly B, McQuillin A, Melle I, Mortensen PB, Mowry BJ, Pato CN, Periyasamy S, Rietschel M, Rujescu D, Simonsen C, St Clair D, Tooney P, Wu JQ, Andreassen OA, Kowalec K, Sullivan PF, Murray RM, Owen MJ, MacCabe JH, O'Donovan MC, Walters JTR; Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC); Ajnakina O, Alameda L, Barnes TRE, Berardi D, Bonora E, Camporesi S, Cleusix M, Conus P, Crespo-Facorro B, D'Andrea G, Demjaha A, Do KQ, Doody GA, Eap CB, Ferchiou A, Di Forti M, Guidi L, Homman L, Jenni R, Joyce EM, Kassoumeri L, Khadimallah I, Lastrina O, Muratori R, Noyan H, O'Neill FA, Pignon B, Restellini R, Richard JR, Schürhoff F, Španiel F, Szöke A, Tarricone I, Tortelli A, Üçok A, Vázquez-Bourgon J.
Pardiñas AF, et al. Among authors: willcocks ir.
JAMA Psychiatry. 2022 Mar 1;79(3):260-269. doi: 10.1001/jamapsychiatry.2021.3799.
JAMA Psychiatry. 2022.
PMID: 35019943
Free PMC article.
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Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia.
Willcocks IR, Legge SE, Nalmpanti M, Mazzeo L, King A, Jansen J, Helthuis M, Owen MJ, O'Donovan MC, Walters JTR, Pardiñas AF.
Willcocks IR, et al.
Front Pharmacol. 2021 Apr 16;12:658734. doi: 10.3389/fphar.2021.658734. eCollection 2021.
Front Pharmacol. 2021.
PMID: 33959025
Free PMC article.
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