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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.
Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Beretta M, et al. Among authors: byrne fl. Diabetes. 2024 Mar 1;73(3):374-384. doi: 10.2337/db23-0233. Diabetes. 2024. PMID: 37870907 Free PMC article.
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Kenwood BM, et al. Among authors: byrne fl. Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634817 Free PMC article.
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.
Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL. Chow JD, et al. Among authors: byrne fl. Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016/j.molmet.2014.02.004. eCollection 2014 Jul. Mol Metab. 2014. PMID: 24944901 Free PMC article.
Metabolic vulnerabilities in endometrial cancer.
Byrne FL, Poon IK, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, Moley KH, Ravichandran KS, Slack-Davis JK, Hoehn KL. Byrne FL, et al. Cancer Res. 2014 Oct 15;74(20):5832-45. doi: 10.1158/0008-5472.CAN-14-0254. Epub 2014 Sep 9. Cancer Res. 2014. PMID: 25205105
Dietary sugar intake increases liver tumor incidence in female mice.
Healy ME, Lahiri S, Hargett SR, Chow JD, Byrne FL, Breen DS, Kenwood BM, Taddeo EP, Lackner C, Caldwell SH, Hoehn KL. Healy ME, et al. Among authors: byrne fl. Sci Rep. 2016 Feb 29;6:22292. doi: 10.1038/srep22292. Sci Rep. 2016. PMID: 26924712 Free PMC article.
The emerging role of long non-coding RNAs in endometrial cancer.
Takenaka K, Chen BJ, Modesitt SC, Byrne FL, Hoehn KL, Janitz M. Takenaka K, et al. Among authors: byrne fl. Cancer Genet. 2016 Oct;209(10):445-455. doi: 10.1016/j.cancergen.2016.09.005. Epub 2016 Sep 13. Cancer Genet. 2016. PMID: 27810073 Review.
49 results