Dai Y - Search Results

1

Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.

Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Beretta M, et al. Among authors: dai y. Diabetes. 2024 Mar 1;73(3):374-384. doi: 10.2337/db23-0233. Diabetes. 2024. PMID: 37870907 Free PMC article.

2

[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.

Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. Among authors: dai y. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.

3

Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers.

Dai Y, Santiago-Rivera JA, Hargett S, Salamoun JM, Hoehn KL, Santos WL. Dai Y, et al. Bioorg Med Chem Lett. 2022 Oct 1;73:128912. doi: 10.1016/j.bmcl.2022.128912. Epub 2022 Jul 28. Bioorg Med Chem Lett. 2022. PMID: 35907607 Free PMC article.

4

Molecular recognition of HIV-1 RNAs with branched peptides.

Peralta AN, Dai Y, Sherpa C, Le Grice SFJ, Santos WL. Peralta AN, et al. Among authors: dai y. Methods Enzymol. 2019;623:373-400. doi: 10.1016/bs.mie.2019.04.021. Epub 2019 May 15. Methods Enzymol. 2019. PMID: 31239054 Free PMC article.

5

Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.

Dai Y, Peralta AN, Wynn JE, Sherpa C, Li H, Verma A, Le Grice SFJ, Santos WL. Dai Y, et al. Bioorg Med Chem. 2019 Apr 15;27(8):1759-1765. doi: 10.1016/j.bmc.2019.03.016. Epub 2019 Mar 7. Bioorg Med Chem. 2019. PMID: 30879859 Free PMC article.

6

Substrate-Assisted, Transition-Metal-Free Diboration of Alkynamides with Mixed Diboron: Regio- and Stereoselective Access to trans-1,2-Vinyldiboronates.

Verma A, Snead RF, Dai Y, Slebodnick C, Yang Y, Yu H, Yao F, Santos WL. Verma A, et al. Among authors: dai y. Angew Chem Int Ed Engl. 2017 Apr 24;56(18):5111-5115. doi: 10.1002/anie.201700946. Epub 2017 Mar 29. Angew Chem Int Ed Engl. 2017. PMID: 28371182

7

Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.

Dai Y, Wynn JE, Peralta AN, Sherpa C, Jayaraman B, Li H, Verma A, Frankel AD, Le Grice SF, Santos WL. Dai Y, et al. J Med Chem. 2018 Nov 8;61(21):9611-9620. doi: 10.1021/acs.jmedchem.8b01076. Epub 2018 Oct 18. J Med Chem. 2018. PMID: 30289719 Free PMC article.

8

Identification and enrichment of a UV-induced degradant of Anagrelide drug substance.

Li H, Ehnstrom J, Milton M, Santos W, Zell M, Dai Y. Li H, et al. Among authors: dai y. J Pharm Biomed Anal. 2023 May 30;229:115352. doi: 10.1016/j.jpba.2023.115352. Epub 2023 Mar 21. J Pharm Biomed Anal. 2023. PMID: 36989665

9

Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.

Liu LK, Dai Y, Abdelwahab H, Sobrado P, Tanner JJ. Liu LK, et al. Among authors: dai y. Biochemistry. 2018 Apr 10;57(14):2065-2068. doi: 10.1021/acs.biochem.8b00190. Epub 2018 Mar 30. Biochemistry. 2018. PMID: 29578336

10

Evidence for the Formation of a Radical-Mediated Flavin-N5 Covalent Intermediate.

Dai Y, Valentino H, Sobrado P. Dai Y, et al. Chembiochem. 2018 Aug 6;19(15):1609-1612. doi: 10.1002/cbic.201800123. Epub 2018 Jun 19. Chembiochem. 2018. PMID: 29776001

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