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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.
Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Beretta M, et al. Among authors: hoehn kl. Diabetes. 2024 Mar 1;73(3):374-384. doi: 10.2337/db23-0233. Diabetes. 2024. PMID: 37870907 Free PMC article.
Insulin resistance is a cellular antioxidant defense mechanism.
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Hoehn KL, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30. Proc Natl Acad Sci U S A. 2009. PMID: 19805130 Free PMC article.
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Kenwood BM, et al. Among authors: hoehn kl. Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634817 Free PMC article.
Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.
Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL. Taddeo EP, et al. Among authors: hoehn kl. Mol Metab. 2013 Nov 26;3(2):124-34. doi: 10.1016/j.molmet.2013.11.003. eCollection 2014 Apr. Mol Metab. 2013. PMID: 24634818 Free PMC article.
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.
Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL. Chow JD, et al. Among authors: hoehn kl. Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016/j.molmet.2014.02.004. eCollection 2014 Jul. Mol Metab. 2014. PMID: 24944901 Free PMC article.
Metabolic vulnerabilities in endometrial cancer.
Byrne FL, Poon IK, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, Moley KH, Ravichandran KS, Slack-Davis JK, Hoehn KL. Byrne FL, et al. Among authors: hoehn kl. Cancer Res. 2014 Oct 15;74(20):5832-45. doi: 10.1158/0008-5472.CAN-14-0254. Epub 2014 Sep 9. Cancer Res. 2014. PMID: 25205105
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