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116 results

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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.
Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Beretta M, et al. Among authors: shah dp. Diabetes. 2024 Mar 1;73(3):374-384. doi: 10.2337/db23-0233. Diabetes. 2024. PMID: 37870907 Free PMC article.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL. Alexopoulos SJ, et al. Among authors: shah dp. Nat Commun. 2020 May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2. Nat Commun. 2020. PMID: 32409697 Free PMC article.
Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.
Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Hargett SR, Childress ES, Salamoun JM, Aleksovska I, Roseblade A, Cranfield C, Rawling T, Quinlan KGR, Morris MJ, Tucker SP, Santos WL, Hoehn KL. Chen SY, et al. Among authors: shah dp. Metabolism. 2021 Apr;117:154724. doi: 10.1016/j.metabol.2021.154724. Epub 2021 Feb 4. Metabolism. 2021. PMID: 33548253
[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.
Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. Among authors: shah dp. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.
6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis.
Salamoun JM, Garcia CJ, Hargett SR, Murray JH, Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Tucker SP, Hoehn KL, Santos WL. Salamoun JM, et al. Among authors: shah dp. J Med Chem. 2020 Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. Epub 2020 May 27. J Med Chem. 2020. PMID: 32392051 Free PMC article.
Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice.
Chen SY, Beretta M, Olzomer EM, Shah DP, Wong DYH, Alexopoulos SJ, Aleksovska I, Salamoun JM, Garcia CJ, Cochran BJ, Rye KA, Smith GC, Byrne FL, Morris MJ, Santos WL, Cantley J, Hoehn KL. Chen SY, et al. Among authors: shah dp. Mol Metab. 2023 Mar;69:101684. doi: 10.1016/j.molmet.2023.101684. Epub 2023 Jan 31. Mol Metab. 2023. PMID: 36731653 Free PMC article.
Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.
Chen SY, Beretta M, Olzomer EM, Alexopoulos SJ, Shah DP, Byrne FL, Salamoun JM, Garcia CJ, Smith GC, Larance M, Philp A, Turner N, Santos WL, Cantley J, Hoehn KL. Chen SY, et al. Among authors: shah dp. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166908. doi: 10.1016/j.bbadis.2023.166908. Epub 2023 Oct 2. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37793464 Free article.
UGCG influences glutamine metabolism of breast cancer cells.
Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS. Schömel N, et al. Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7. Sci Rep. 2019. PMID: 31666638 Free PMC article.
Genome-wide association study identifies high-impact susceptibility loci for HCC in North America.
Hassan MM, Li D, Han Y, Byun J, Hatia RI, Long E, Choi J, Kelley RK, Cleary SP, Lok AS, Bracci P, Permuth JB, Bucur R, Yuan JM, Singal AG, Jalal PK, Ghobrial RM, Santella RM, Kono Y, Shah DP, Nguyen MH, Liu G, Parikh ND, Kim R, Wu HC, El-Serag H, Chang P, Li Y, Chun YS, Lee SS, Gu J, Hawk E, Sun R, Huff C, Rashid A, Amin HM, Beretta L, Wolff RA, Antwi SO, Patt Y, Hwang LY, Klein AP, Zhang K, Schmidt MA, White DL, Goss JA, Khaderi SA, Marrero JA, Cigarroa FG, Shah PK, Kaseb AO, Roberts LR, Amos CI. Hassan MM, et al. Among authors: shah dp. Hepatology. 2024 Feb 20. doi: 10.1097/HEP.0000000000000800. Online ahead of print. Hepatology. 2024. PMID: 38381705
Inter and intra-host diversity of RSV in hematopoietic stem cell transplant adults with normal and delayed viral clearance.
Avadhanula V, Agustinho DP, Menon VK, Chemaly RF, Shah DP, Qin X, Surathu A, Doddapaneni H, Muzny DM, Metcalf GA, Cregeen SJ, Gibbs RA, Petrosino JF, Sedlazeck FJ, Piedra PA. Avadhanula V, et al. Among authors: shah dp. Virus Evol. 2023 Dec 28;10(1):vead086. doi: 10.1093/ve/vead086. eCollection 2024. Virus Evol. 2023. PMID: 38361816 Free PMC article.
116 results