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Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.
Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL, Hoehn KL. Beretta M, et al. Among authors: turner n. Diabetes. 2024 Mar 1;73(3):374-384. doi: 10.2337/db23-0233. Diabetes. 2024. PMID: 37870907 Free PMC article.
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM. Turner N, et al. Diabetes. 2008 May;57(5):1414-8. doi: 10.2337/db07-1552. Epub 2008 Feb 19. Diabetes. 2008. PMID: 18285556
IRS1-independent defects define major nodes of insulin resistance.
Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE. Hoehn KL, et al. Among authors: turner n. Cell Metab. 2008 May;7(5):421-33. doi: 10.1016/j.cmet.2008.04.005. Cell Metab. 2008. PMID: 18460333 Free PMC article.
Insulin resistance is a cellular antioxidant defense mechanism.
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Hoehn KL, et al. Among authors: turner n. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30. Proc Natl Acad Sci U S A. 2009. PMID: 19805130 Free PMC article.
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.
Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ. Hoehn KL, et al. Among authors: turner n. Cell Metab. 2010 Jan;11(1):70-6. doi: 10.1016/j.cmet.2009.11.008. Cell Metab. 2010. PMID: 20074529 Free PMC article.
Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.
Hoehn KL, Turner N, Cooney GJ, James DE. Hoehn KL, et al. Among authors: turner n. J Biol Chem. 2012 May 4;287(19):15801; author reply 15802. doi: 10.1074/jbc.O112.356915. J Biol Chem. 2012. PMID: 22563100 Free PMC article. No abstract available.
Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).
Bell-Anderson KS, Funnell AP, Williams H, Mat Jusoh H, Scully T, Lim WF, Burdach JG, Mak KS, Knights AJ, Hoy AJ, Nicholas HR, Sainsbury A, Turner N, Pearson RC, Crossley M. Bell-Anderson KS, et al. Among authors: turner n. Diabetes. 2013 Aug;62(8):2728-37. doi: 10.2337/db12-1745. Epub 2013 Apr 30. Diabetes. 2013. PMID: 23633521 Free PMC article.
1,876 results