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Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.
Williams AT, Chen J, Coley K, Batini C, Izquierdo A, Packer R, Abner E, Kanoni S, Shepherd DJ, Free RC, Hollox EJ, Brunskill NJ, Ntalla I, Reeve N, Brightling CE, Venn L, Adams E, Bee C, Wallace SE, Pareek M, Hansell AL, Esko T; Estonian Biobank Research Team; Stow D, Jacobs BM, van Heel DA; Genes & Health Research Team; Hennah W, Rao BS, Dudbridge F, Wain LV, Shrine N, Tobin MD, John C. Williams AT, et al. Among authors: hennah w. Nat Commun. 2023 Oct 23;14(1):6713. doi: 10.1038/s41467-023-42284-5. Nat Commun. 2023. PMID: 37872160 Free PMC article.
DeepPheWAS: an R package for phenotype generation and association analysis for phenome-wide association studies.
Packer RJ, Williams AT, Hennah W, Eisenberg MT, Shrine N, Fawcett KA, Pearson W, Guyatt AL, Edris A, Hollox EJ, Marttila M, Rao BS, Bratty JR, Wain LV, Dudbridge F, Tobin MD. Packer RJ, et al. Among authors: hennah w. Bioinformatics. 2023 Apr 3;39(4):btad073. doi: 10.1093/bioinformatics/btad073. Bioinformatics. 2023. PMID: 36744935 Free PMC article.
Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population.
Sinha V, Ukkola-Vuoti L, Ortega-Alonso A, Torniainen-Holm M, Therman S, Tuulio-Henriksson A, Jylhä P, Kaprio J, Hovatta I, Isometsä E, Cannon TD, Lönnqvist J, Paunio T, Suvisaari J, Hennah W. Sinha V, et al. Among authors: hennah w. Mol Psychiatry. 2021 Mar;26(3):816-824. doi: 10.1038/s41380-019-0429-x. Epub 2019 May 28. Mol Psychiatry. 2021. PMID: 31138891
Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia.
Ukkola-Vuoti L, Torniainen-Holm M, Ortega-Alonso A, Sinha V, Tuulio-Henriksson A, Paunio T, Lönnqvist J, Suvisaari J, Hennah W. Ukkola-Vuoti L, et al. Among authors: hennah w. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:159-167. doi: 10.1016/j.pnpbp.2018.07.003. Epub 2018 Jul 18. Prog Neuropsychopharmacol Biol Psychiatry. 2019. PMID: 30030132
The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484.
Bradshaw NJ, Ukkola-Vuoti L, Pankakoski M, Zheutlin AB, Ortega-Alonso A, Torniainen-Holm M, Sinha V, Therman S, Paunio T, Suvisaari J, Lönnqvist J, Cannon TD, Haukka J, Hennah W. Bradshaw NJ, et al. Among authors: hennah w. Open Biol. 2017 Nov;7(11):170153. doi: 10.1098/rsob.170153. Open Biol. 2017. PMID: 29142105 Free PMC article.
Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.
Teng S, Thomson PA, McCarthy S, Kramer M, Muller S, Lihm J, Morris S, Soares DC, Hennah W, Harris S, Camargo LM, Malkov V, McIntosh AM, Millar JK, Blackwood DH, Evans KL, Deary IJ, Porteous DJ, McCombie WR. Teng S, et al. Among authors: hennah w. Mol Psychiatry. 2018 May;23(5):1270-1277. doi: 10.1038/mp.2017.115. Epub 2017 Jun 20. Mol Psychiatry. 2018. PMID: 28630456 Free PMC article.
Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR. Ramos A, et al. Among authors: hennah w. Hum Mol Genet. 2014 Nov 15;23(22):5859-65. doi: 10.1093/hmg/ddu303. Epub 2014 Jun 16. Hum Mol Genet. 2014. PMID: 24934694 Free PMC article.
39 results