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Compelling evidence from meta-epidemiological studies demonstrates overestimation of effects in randomized trials that fail to optimize randomization and blind patients and outcome assessors.
Wang Y, Parpia S, Couban R, Wang Q, Armijo-Olivo S, Bassler D, Briel M, Brignardello-Petersen R, Gluud LL, Keitz SA, Letelier LM, Ravaud P, Schulz KF, Siemieniuk RAC, Zeraatkar D, Guyatt GH. Wang Y, et al. Among authors: bassler d. J Clin Epidemiol. 2024 Jan;165:111211. doi: 10.1016/j.jclinepi.2023.11.001. Epub 2023 Nov 7. J Clin Epidemiol. 2024. PMID: 37939743
Instruments assessing risk of bias of randomized trials frequently included items that are not addressing risk of bias issues.
Wang Y, Ghadimi M, Wang Q, Hou L, Zeraatkar D, Iqbal A, Ho C, Yao L, Hu M, Ye Z, Couban R, Armijo-Olivo S, Bassler D, Briel M, Gluud LL, Glasziou P, Jackson R, Keitz SA, Letelier LM, Ravaud P, Schulz KF, Siemieniuk RAC, Brignardello-Petersen R, Guyatt GH. Wang Y, et al. Among authors: bassler d. J Clin Epidemiol. 2022 Dec;152:218-225. doi: 10.1016/j.jclinepi.2022.10.018. Epub 2022 Oct 28. J Clin Epidemiol. 2022. PMID: 36424692
Systematic reviewers neglect bias that results from trials stopped early for benefit.
Bassler D, Ferreira-Gonzalez I, Briel M, Cook DJ, Devereaux PJ, Heels-Ansdell D, Kirpalani H, Meade MO, Montori VM, Rozenberg A, Schünemann HJ, Guyatt GH. Bassler D, et al. J Clin Epidemiol. 2007 Sep;60(9):869-73. doi: 10.1016/j.jclinepi.2006.12.006. Epub 2007 Apr 11. J Clin Epidemiol. 2007. PMID: 17689802 Review.
Randomized trials addressing a similar question are commonly published after a trial stopped early for benefit.
Murad MH, Guyatt GH, Domecq JP, Vernooij RWM, Erwin PJ, Meerpohl JJ, Prutsky GJ, Akl EA, Mueller K, Bassler D, Schandelmaier S, Walter SD, Busse JW, Kasenda B, Pagano G, Pardo-Hernandez H, Montori VM, Wang Z, Briel M. Murad MH, et al. Among authors: bassler d. J Clin Epidemiol. 2017 Feb;82:12-19. doi: 10.1016/j.jclinepi.2016.10.006. Epub 2016 Nov 8. J Clin Epidemiol. 2017. PMID: 27832953 Free article. Review.
Problems of stopping trials early.
Guyatt GH, Briel M, Glasziou P, Bassler D, Montori VM. Guyatt GH, et al. Among authors: bassler d. BMJ. 2012 Jun 15;344:e3863. doi: 10.1136/bmj.e3863. BMJ. 2012. PMID: 22705814 No abstract available.
Randomized trials published in higher vs. lower impact journals differ in design, conduct, and analysis.
Bala MM, Akl EA, Sun X, Bassler D, Mertz D, Mejza F, Vandvik PO, Malaga G, Johnston BC, Dahm P, Alonso-Coello P, Diaz-Granados N, Srinathan SK, Hassouneh B, Briel M, Busse JW, You JJ, Walter SD, Altman DG, Guyatt GH. Bala MM, et al. Among authors: bassler d. J Clin Epidemiol. 2013 Mar;66(3):286-95. doi: 10.1016/j.jclinepi.2012.10.005. J Clin Epidemiol. 2013. PMID: 23347852
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid.
Akl EA, Sun X, Busse JW, Johnston BC, Briel M, Mulla S, You JJ, Bassler D, Lamontagne F, Vera C, Alshurafa M, Katsios CM, Heels-Ansdell D, Zhou Q, Mills E, Guyatt GH. Akl EA, et al. Among authors: bassler d. J Clin Epidemiol. 2012 Mar;65(3):262-7. doi: 10.1016/j.jclinepi.2011.04.015. Epub 2011 Dec 24. J Clin Epidemiol. 2012. PMID: 22200346
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.
Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, Heels-Ansdell D, Walter SD, Guyatt GH; STOPIT-2 Study Group; Flynn DN, Elamin MB, Murad MH, Abu Elnour NO, Lampropulos JF, Sood A, Mullan RJ, Erwin PJ, Bankhead CR, Perera R, Ruiz Culebro C, You JJ, Mulla SM, Kaur J, Nerenberg KA, Schünemann H, Cook DJ, Lutz K, Ribic CM, Vale N, Malaga G, Akl EA, Ferreira-Gonzalez I, Alonso-Coello P, Urrutia G, Kunz R, Bucher HC, Nordmann AJ, Raatz H, da Silva SA, Tuche F, Strahm B, Djulbegovic B, Adhikari NK, Mills EJ, Gwadry-Sridhar F, Kirpalani H, Soares HP, Karanicolas PJ, Burns KE, Vandvik PO, Coto-Yglesias F, Chrispim PP, Ramsay T. Bassler D, et al. JAMA. 2010 Mar 24;303(12):1180-7. doi: 10.1001/jama.2010.310. JAMA. 2010. PMID: 20332404 Review.
251 results