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A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sri S, Greenstein A, Granata A, Collcutt A, Jochems ACC, McColl BW, Castro BD, Webber C, Reyes CA, Hall C, Lawrence CB, Hawkes C, Pegasiou-Davies CM, Gibson C, Crawford CL, Smith C, Vivien D, McLean FH, Wiseman F, Brezzo G, Lalli G, Pritchard HAT, Markus HS, Bravo-Ferrer I, Taylor J, Leiper J, Berwick J, Gan J, Gallacher J, Moss J, Goense J, McMullan L, Work L, Evans L, Stringer MS, Ashford M, Abulfadl M, Conlon N, Malhotra P, Bath P, Canter R, Brown R, Ince S, Anderle S, Young S, Quick S, Szymkowiak S, Hill S, Allan S, Wang T, Quinn T, Procter T, Farr TD, Zhao X, Yang Z, Hainsworth AH, Wardlaw JM. Sri S, et al. Among authors: wiseman f. Cereb Circ Cogn Behav. 2023 Oct 11;5:100189. doi: 10.1016/j.cccb.2023.100189. eCollection 2023. Cereb Circ Cogn Behav. 2023. PMID: 37941765 Free PMC article. Review.
Cell models for Down syndrome-Alzheimer's disease research.
Wu Y, West NR, Bhattacharyya A, Wiseman FK. Wu Y, et al. Among authors: wiseman fk. Neuronal Signal. 2022 Apr 8;6(1):NS20210054. doi: 10.1042/NS20210054. eCollection 2022 Apr. Neuronal Signal. 2022. PMID: 35449591 Free PMC article. Review.
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium; Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D. Alić I, et al. Mol Psychiatry. 2021 Oct;26(10):5766-5788. doi: 10.1038/s41380-020-0806-5. Epub 2020 Jul 10. Mol Psychiatry. 2021. PMID: 32647257 Free PMC article.
Gene expression dysregulation domains are not a specific feature of Down syndrome.
Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ. Ahlfors H, et al. Among authors: wiseman f. Nat Commun. 2019 Jun 6;10(1):2489. doi: 10.1038/s41467-019-10129-9. Nat Commun. 2019. PMID: 31171815 Free PMC article.
57 results