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Predicting multiple conformations via sequence clustering and AlphaFold2.
Wayment-Steele HK, Ojoawo A, Otten R, Apitz JM, Pitsawong W, Hömberger M, Ovchinnikov S, Colwell L, Kern D. Wayment-Steele HK, et al. Among authors: colwell l. Nature. 2024 Jan;625(7996):832-839. doi: 10.1038/s41586-023-06832-9. Epub 2023 Nov 13. Nature. 2024. PMID: 37956700 Free PMC article.
The interface of protein structure, protein biophysics, and molecular evolution.
Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, Lakner C, Lartillot N, Lovell SC, Naylor G, Perica T, Pollock DD, Pupko T, Regan L, Roger A, Rubinstein N, Shakhnovich E, Sjölander K, Sunyaev S, Teufel AI, Thorne JL, Thornton JW, Weinreich DM, Whelan S. Liberles DA, et al. Among authors: colwell lj. Protein Sci. 2012 Jun;21(6):769-85. doi: 10.1002/pro.2071. Epub 2012 Apr 23. Protein Sci. 2012. PMID: 22528593 Free PMC article. Review.
Deep diversification of an AAV capsid protein by machine learning.
Bryant DH, Bashir A, Sinai S, Jain NK, Ogden PJ, Riley PF, Church GM, Colwell LJ, Kelsic ED. Bryant DH, et al. Nat Biotechnol. 2021 Jun;39(6):691-696. doi: 10.1038/s41587-020-00793-4. Epub 2021 Feb 11. Nat Biotechnol. 2021. PMID: 33574611
Using deep learning to annotate the protein universe.
Bileschi ML, Belanger D, Bryant DH, Sanderson T, Carter B, Sculley D, Bateman A, DePristo MA, Colwell LJ. Bileschi ML, et al. Among authors: colwell lj. Nat Biotechnol. 2022 Jun;40(6):932-937. doi: 10.1038/s41587-021-01179-w. Epub 2022 Feb 21. Nat Biotechnol. 2022. PMID: 35190689
Hallucinating functional protein sequences.
Belanger D, Colwell LJ. Belanger D, et al. Among authors: colwell lj. Nat Biotechnol. 2023 Aug;41(8):1073-1074. doi: 10.1038/s41587-022-01634-2. Nat Biotechnol. 2023. PMID: 36702894 No abstract available.
123 results