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3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex.
Vue Z, Garza-Lopez E, Neikirk K, Katti P, Vang L, Beasley H, Shao J, Marshall AG, Crabtree A, Murphy AC, Jenkins BC, Prasad P, Evans C, Taylor B, Mungai M, Killion M, Stephens D, Christensen TA, Lam J, Rodriguez B, Phillips MA, Daneshgar N, Koh HJ, Koh A, Davis J, Devine N, Saleem M, Scudese E, Arnold KR, Vanessa Chavarin V, Daniel Robinson R, Chakraborty M, Gaddy JA, Sweetwyne MT, Wilson G, Zaganjor E, Kezos J, Dondi C, Reddy AK, Glancy B, Kirabo A, Quintana AM, Dai DF, Ocorr K, Murray SA, Damo SM, Exil V, Riggs B, Mobley BC, Gomez JA, McReynolds MR, Hinton A Jr. Vue Z, et al. Among authors: mcreynolds mr. Aging Cell. 2023 Dec;22(12):e14009. doi: 10.1111/acel.14009. Epub 2023 Nov 13. Aging Cell. 2023. PMID: 37960952 Free PMC article.
NAD precursors cycle between host tissues and the gut microbiome.
Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, Davidson SM, Thaiss CA, Migaud ME, Rabinowitz JD, Baur JA. Chellappa K, et al. Among authors: mcreynolds mr. Cell Metab. 2022 Dec 6;34(12):1947-1959.e5. doi: 10.1016/j.cmet.2022.11.004. Cell Metab. 2022. PMID: 36476934 Free PMC article.
SLC25A51 is a mammalian mitochondrial NAD+ transporter.
Luongo TS, Eller JM, Lu MJ, Niere M, Raith F, Perry C, Bornstein MR, Oliphint P, Wang L, McReynolds MR, Migaud ME, Rabinowitz JD, Johnson FB, Johnsson K, Ziegler M, Cambronne XA, Baur JA. Luongo TS, et al. Among authors: mcreynolds mr. Nature. 2020 Dec;588(7836):174-179. doi: 10.1038/s41586-020-2741-7. Epub 2020 Sep 9. Nature. 2020. PMID: 32906142 Free PMC article.
Spatially resolved isotope tracing reveals tissue metabolic activity.
Wang L, Xing X, Zeng X, Jackson SR, TeSlaa T, Al-Dalahmah O, Samarah LZ, Goodwin K, Yang L, McReynolds MR, Li X, Wolff JJ, Rabinowitz JD, Davidson SM. Wang L, et al. Among authors: mcreynolds mr. Nat Methods. 2022 Feb;19(2):223-230. doi: 10.1038/s41592-021-01378-y. Epub 2022 Feb 7. Nat Methods. 2022. PMID: 35132243 Free PMC article.
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. Yang L, et al. Among authors: mcreynolds mr. Cell Metab. 2020 Apr 7;31(4):809-821.e6. doi: 10.1016/j.cmet.2020.02.017. Epub 2020 Mar 17. Cell Metab. 2020. PMID: 32187526 Free PMC article.
Metabolite discovery through global annotation of untargeted metabolomics data.
Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella AD, Shen Y, Cowan A, McReynolds MR, Kennedy BJ, Lato AM, Campagna SR, Singh M, Rabinowitz JD. Chen L, et al. Among authors: mcreynolds mr. Nat Methods. 2021 Nov;18(11):1377-1385. doi: 10.1038/s41592-021-01303-3. Epub 2021 Oct 28. Nat Methods. 2021. PMID: 34711973 Free PMC article.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Among authors: mcreynolds mr. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. Nature. 2021. PMID: 33473210 Free PMC article.
Age-related NAD+ decline.
McReynolds MR, Chellappa K, Baur JA. McReynolds MR, et al. Exp Gerontol. 2020 Feb 22;134:110888. doi: 10.1016/j.exger.2020.110888. Online ahead of print. Exp Gerontol. 2020. PMID: 32097708 Free PMC article. Review.
57 results