Liu J - Search Results

1

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.

Xie L, Sheehy RN, Xiong Y, Muneer A, Wrobel JA, Park KS, Velez J, Liu J, Luo YJ, Li YD, Quintanilla L, Li Y, Xu C, Deshmukh M, Wen Z, Jin J, Song J, Chen X. Xie L, et al. Among authors: liu j. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297491. doi: 10.1101/2023.10.25.23297491. medRxiv. 2023. PMID: 37961307 Free PMC article. Preprint.

2

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.

Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. Xiong Y, et al. Among authors: liu j. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. J Am Chem Soc. 2022. PMID: 36448571 Free PMC article.

3

Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins.

Wang Z, Liu J, Chen H, Qiu X, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: liu j. J Am Chem Soc. 2023 May 17;145(19):10872-10879. doi: 10.1021/jacs.3c02783. Epub 2023 May 4. J Am Chem Soc. 2023. PMID: 37141574 Free PMC article.

4

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.

Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: liu j. J Am Chem Soc. 2024 Mar 20;146(11):7584-7593. doi: 10.1021/jacs.3c13646. Epub 2024 Mar 12. J Am Chem Soc. 2024. PMID: 38469801 Free PMC article.

5

USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.

Liu J, Hu X, Luo K, Xiong Y, Chen L, Wang Z, Inuzuka H, Qian C, Yu X, Xie L, Muneer A, Zhang D, Paulo JA, Chen X, Jin J, Wei W. Liu J, et al. J Am Chem Soc. 2024 Apr 10. doi: 10.1021/jacs.4c02373. Online ahead of print. J Am Chem Soc. 2024. PMID: 38597345

6

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2.

Wang Z, Liu J, Qiu X, Zhang D, Inuzuka H, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: liu j. J Am Chem Soc. 2023 Oct 11;145(40):21871-21878. doi: 10.1021/jacs.3c06023. Epub 2023 Sep 29. J Am Chem Soc. 2023. PMID: 37774414 Free PMC article.

7

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.

Yu X, Li D, Kottur J, Kim HS, Herring LE, Yu Y, Xie L, Hu X, Chen X, Cai L, Liu J, Aggarwal AK, Wang GG, Jin J. Yu X, et al. Among authors: liu j. J Med Chem. 2023 Dec 14;66(23):16168-16186. doi: 10.1021/acs.jmedchem.3c01521. Epub 2023 Nov 29. J Med Chem. 2023. PMID: 38019706

8

Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.

Xiong Y, Greschik H, Johansson C, Seifert L, Gamble V, Park KS, Fagan V, Li F, Chau I, Vedadi M, Arrowsmith CH, Brennan P, Fedorov O, Jung M, Farnie G, Liu J, Oppermann U, Schüle R, Jin J. Xiong Y, et al. Among authors: liu j. J Med Chem. 2024 Apr 11;67(7):5837-5853. doi: 10.1021/acs.jmedchem.4c00121. Epub 2024 Mar 27. J Med Chem. 2024. PMID: 38533580

9

Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader.

Yu X, Wang J, Gong W, Ma A, Shen Y, Zhang C, Liu X, Cai L, Liu J, Wang GG, Jin J. Yu X, et al. Among authors: liu j, liu x. Oncogene. 2023 Mar;42(13):994-1009. doi: 10.1038/s41388-023-02618-5. Epub 2023 Feb 7. Oncogene. 2023. PMID: 36747009 Free PMC article.

10

An MDM2 degrader for treatment of acute leukemias.

Marcellino BK, Yang X, Ümit Kaniskan H, Brady C, Chen H, Chen K, Qiu X, Clementelli C, Herschbein L, Li Z, Elghaity-Beckley S, Arandela J, Kelly B, Hoffman R, Liu J, Xiong Y, Jin J, Shih AH. Marcellino BK, et al. Among authors: liu j. Leukemia. 2023 Feb;37(2):370-378. doi: 10.1038/s41375-022-01735-6. Epub 2022 Oct 29. Leukemia. 2023. PMID: 36309559 Free PMC article.

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