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Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Xie L, Sheehy RN, Xiong Y, Muneer A, Wrobel JA, Park KS, Velez J, Liu J, Luo YJ, Li YD, Quintanilla L, Li Y, Xu C, Deshmukh M, Wen Z, Jin J, Song J, Chen X. Xie L, et al. Among authors: xiong y. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297491. doi: 10.1101/2023.10.25.23297491. medRxiv. 2023. PMID: 37961307 Free PMC article. Preprint.
Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.
Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X. Wang L, et al. Among authors: xiong y. bioRxiv [Preprint]. 2020 Nov 16:2020.11.14.382416. doi: 10.1101/2020.11.14.382416. bioRxiv. 2020. PMID: 33236014 Free PMC article. Updated. Preprint.
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Park KS, Xiong Y, Yim H, Velez J, Babault N, Kumar P, Liu J, Jin J. Park KS, et al. Among authors: xiong y. J Med Chem. 2022 Aug 11;65(15):10506-10522. doi: 10.1021/acs.jmedchem.2c00652. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763668 Free PMC article.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X. Muneer A, et al. Among authors: xiong y. Cell Chem Biol. 2023 Dec 21;30(12):1525-1541.e7. doi: 10.1016/j.chembiol.2023.09.012. Epub 2023 Oct 19. Cell Chem Biol. 2023. PMID: 37858336
Discovery of the First-in-class G9a/GLP PROTAC Degrader.
Velez J, Han Y, Yim H, Yang P, Deng Z, Park KS, Kabir M, Kaniskan HÜ, Xiong Y, Jin J. Velez J, et al. Among authors: xiong y. bioRxiv [Preprint]. 2024 Feb 29:2024.02.26.582210. doi: 10.1101/2024.02.26.582210. bioRxiv. 2024. PMID: 38464025 Free PMC article. Updated. Preprint.
10,298 results
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