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Matched vs Nonmatched Placebos in a Randomized Trial of COVID-19 Treatments.
Reis G, Savassi LCM, Ferreira TS, Reis LLF, Simplicio MIC, Ribeiro LB, Silva EADSM, Lat PK, Harari O, Forrest JI, Dron L, Park JJH, Thorlund K, Mills EJ. Reis G, et al. Among authors: harari o. JAMA Netw Open. 2024 May 1;7(5):e2410335. doi: 10.1001/jamanetworkopen.2024.10335. JAMA Netw Open. 2024. PMID: 38767921 Free PMC article. Clinical Trial.
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease.
Eteleeb AM, Novotny BC, Tarraga CS, Sohn C, Dhungel E, Brase L, Nallapu A, Buss J, Farias F, Bergmann K, Bradley J, Norton J, Gentsch J, Wang F, Davis AA, Morris JC, Karch CM, Perrin RJ, Benitez BA, Harari O. Eteleeb AM, et al. Among authors: harari o. PLoS Biol. 2024 Apr 30;22(4):e3002607. doi: 10.1371/journal.pbio.3002607. eCollection 2024 Apr. PLoS Biol. 2024. PMID: 38687811 Free PMC article.
Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning.
Wipperman MF, Lin AZ, Gayvert KM, Lahner B, Somersan-Karakaya S, Wu X, Im J, Lee M, Koyani B, Setliff I, Thakur M, Duan D, Breazna A, Wang F, Lim WK, Halasz G, Urbanek J, Patel Y, Atwal GS, Hamilton JD, Stuart S, Levy O, Avbersek A, Alaj R, Hamon SC, Harari O. Wipperman MF, et al. Among authors: harari o. Elife. 2024 Apr 30;13:e86132. doi: 10.7554/eLife.86132. Online ahead of print. Elife. 2024. PMID: 38686919 Free article.
Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS). Xicota L, et al. Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21. Alzheimers Dement. 2024. PMID: 38380866 Free PMC article.
Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ozen A, Chongsrisawat V, Sefer AP, Kolukisa B, Jalbert JJ, Meagher KA, Brackin T, Feldman HB, Baris S, Karakoc-Aydiner E, Ergelen R, Fuss IJ, Moorman H, Suratannon N, Suphapeetiporn K, Perlee L, Harari OA, Yancopoulos GD, Lenardo MJ; Pozelimab CHAPLE Working Group. Ozen A, et al. Among authors: harari oa. Lancet. 2024 Feb 17;403(10427):645-656. doi: 10.1016/S0140-6736(23)02358-9. Epub 2024 Jan 23. Lancet. 2024. PMID: 38278170 Clinical Trial.
Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain.
Somersan-Karakaya S, Turner KC, Cortes-Burgos L, Miller J, LaCroix-Fralish M, Logovinsky V, Patel Y, Torres R, Ganguly S, Breazna A, DeVeaux M, Bhore R, Gao M, Delfino FJ, Rafique A, Fairhurst JL, Hunt C, Babb R, Badithe A, Poueymirou WT, Surowitz R, Rottey S, Murphy AJ, Harari O, Macdonald LE, Croll SD. Somersan-Karakaya S, et al. Among authors: harari o. Neurobiol Pain. 2023 Jun 26;14:100136. doi: 10.1016/j.ynpai.2023.100136. eCollection 2023 Aug-Dec. Neurobiol Pain. 2023. PMID: 38099276 Free PMC article.
A therapeutic strategy to target distinct sources of IgE and durably reverse allergy.
Limnander A, Kaur N, Asrat S, Tasker C, Boyapati A, Ben LH, Janczy J, Pedraza P, Abreu P, Chen WC, Godin S, Daniel BJ, Chin H, DeVeaux M, Rodriguez Lorenc K, Sirulnik A, Harari O, Stahl N, Sleeman MA, Murphy AJ, Yancopoulos GD, Orengo JM. Limnander A, et al. Among authors: harari o. Sci Transl Med. 2023 Dec 13;15(726):eadf9561. doi: 10.1126/scitranslmed.adf9561. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091405
151 results