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In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel.
J Med Chem. 2024 May 23. doi: 10.1021/acs.jmedchem.4c00268. Online ahead of print.
J Med Chem. 2024.
PMID: 38782404
Case report: Marked electroclinical improvement by fluoxetine treatment in a patient with KCNT1-related drug-resistant focal epilepsy.
Mosca I, Freri E, Ambrosino P, Belperio G, Granata T, Canafoglia L, Ragona F, Solazzi R, Filareto I, Castellotti B, Messina G, Gellera C, DiFrancesco JC, Soldovieri MV, Taglialatela M.
Mosca I, et al. Among authors: belperio g.
Front Cell Neurosci. 2024 Apr 4;18:1367838. doi: 10.3389/fncel.2024.1367838. eCollection 2024.
Front Cell Neurosci. 2024.
PMID: 38644974
Free PMC article.
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De novo variants in KCNA3 cause developmental and epileptic encephalopathy.
Soldovieri MV, Ambrosino P, Mosca I, Servettini I, Pietrunti F, Belperio G; KCNA3 study group; Syrbe S, Taglialatela M, Lemke JR.
Soldovieri MV, et al. Among authors: belperio g.
Ann Neurol. 2024 Feb;95(2):365-376. doi: 10.1002/ana.26826. Epub 2023 Dec 28.
Ann Neurol. 2024.
PMID: 37964487
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KCNT2-Related Disorders: Phenotypes, Functional, and Pharmacological Properties.
Cioclu MC, Mosca I, Ambrosino P, Puzo D, Bayat A, Wortmann SB, Koch J, Strehlow V, Shirai K, Matsumoto N, Sanders SJ, Michaud V, Legendre M, Riva A, Striano P, Muhle H, Pendziwiat M, Lesca G, Mangano GD, Nardello R; KCNT2-study group; Lemke JR, Møller RS, Soldovieri MV, Rubboli G, Taglialatela M.
Cioclu MC, et al.
Ann Neurol. 2023 Aug;94(2):332-349. doi: 10.1002/ana.26662. Epub 2023 May 22.
Ann Neurol. 2023.
PMID: 37062836
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Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2.
Belperio G, Corso C, Duarte CB, Mele M.
Belperio G, et al.
J Mol Neurosci. 2022 Jul;72(7):1500-1515. doi: 10.1007/s12031-022-02041-7. Epub 2022 Jul 12.
J Mol Neurosci. 2022.
PMID: 35819636
Review.
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