Tan JA - Search Results

1

Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders.

Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O. Chu T, et al. Among authors: tan ja. RSC Med Chem. 2023 Sep 14;14(11):2342-2347. doi: 10.1039/d3md00302g. eCollection 2023 Nov 15. RSC Med Chem. 2023. PMID: 37974969

2

Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.

Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. Cil O, et al. Among authors: tan ja. Eur J Med Chem. 2023 Mar 5;249:115149. doi: 10.1016/j.ejmech.2023.115149. Epub 2023 Jan 27. Eur J Med Chem. 2023. PMID: 36724632 Free PMC article.

3

Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.

Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Haggie PM, et al. Among authors: tan ja. FASEB J. 2016 Jun;30(6):2187-97. doi: 10.1096/fj.201600223R. Epub 2016 Mar 1. FASEB J. 2016. PMID: 26932931 Free PMC article.

4

Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.

Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Cil O, et al. Among authors: tan ja. J Am Soc Nephrol. 2016 Dec;27(12):3706-3714. doi: 10.1681/ASN.2015121312. Epub 2016 May 6. J Am Soc Nephrol. 2016. PMID: 27153921 Free PMC article.

5

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

Lee S, Phuan PW, Felix CM, Tan JA, Levin MH, Verkman AS. Lee S, et al. Among authors: tan ja. J Med Chem. 2017 Feb 9;60(3):1210-1218. doi: 10.1021/acs.jmedchem.6b01792. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28099811 Free PMC article.

6

SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.

Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. Haggie PM, et al. Among authors: tan ja. JCI Insight. 2018 Jul 26;3(14):e121370. doi: 10.1172/jci.insight.121370. eCollection 2018 Jul 26. JCI Insight. 2018. PMID: 30046015 Free PMC article.

7

Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin).

Zhu JS, Lu JY, Tan JA, Rivera AA, Phuan PW, Shatskikh ME, Son JH, Haggie PM, Verkman AS, Kurth MJ. Zhu JS, et al. Among authors: tan ja. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2119-2123. doi: 10.1016/j.bmcl.2019.07.003. Epub 2019 Jul 3. Bioorg Med Chem Lett. 2019. PMID: 31281021 Free PMC article.

8

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.

Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Haggie PM, et al. Among authors: tan ja. J Biol Chem. 2017 Jan 20;292(3):771-785. doi: 10.1074/jbc.M116.764720. Epub 2016 Nov 28. J Biol Chem. 2017. PMID: 27895116 Free PMC article.

9

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. Phuan PW, et al. Among authors: tan ja. SLAS Discov. 2018 Sep;23(8):823-831. doi: 10.1177/2472555218763310. Epub 2018 Mar 13. SLAS Discov. 2018. PMID: 29533733 Free PMC article.

10

Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.

Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. Phuan PW, et al. Among authors: tan ja. J Cyst Fibros. 2018 Sep;17(5):595-606. doi: 10.1016/j.jcf.2018.05.010. Epub 2018 Jun 12. J Cyst Fibros. 2018. PMID: 29903467 Free PMC article.

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