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Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?
Wetten A, Ogle L, Mells G, Hegade VS, Jopson L, Corrigan M, Palmer J, Johansson M, Bäckström T, Doverskog M, Jones DEJ, Dyson JK. Wetten A, et al. Among authors: doverskog m. Can J Gastroenterol Hepatol. 2022 Dec 6;2022:3618090. doi: 10.1155/2022/3618090. eCollection 2022. Can J Gastroenterol Hepatol. 2022. PMID: 36523650 Free PMC article.
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.
Llansola M, Arenas YM, Sancho-Alonso M, Mincheva G, Palomares-Rodriguez A, Doverskog M, Izquierdo-Altarejos P, Felipo V. Llansola M, et al. Among authors: doverskog m. Front Pharmacol. 2024 Mar 15;15:1358323. doi: 10.3389/fphar.2024.1358323. eCollection 2024. Front Pharmacol. 2024. PMID: 38560359 Free PMC article. Review.
Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
Mincheva G, Gimenez-Garzo C, Izquierdo-Altarejos P, Martinez-Garcia M, Doverskog M, Blackburn TP, Hällgren A, Bäckström T, Llansola M, Felipo V. Mincheva G, et al. Among authors: doverskog m. CNS Neurosci Ther. 2022 Nov;28(11):1861-1874. doi: 10.1111/cns.13926. Epub 2022 Jul 26. CNS Neurosci Ther. 2022. PMID: 35880480 Free PMC article.
A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.
Montagnese S, Lauridsen M, Vilstrup H, Zarantonello L, Lakner G, Fitilev S, Zupanets I, Kozlova I, Bunkova E, Tomasiewicz K, Berglund JE, Rorsman F, Hagström H, Kechagias S, Ocklind CE, Mauney J, Thunarf F, Mokhatarani M, Bäckström T, Doverskog M, Lins LE, Månsson M, Samuelson P, Nilsson D, Schalling M, Johansson M, Arlander E, Scharschmidt BF. Montagnese S, et al. Among authors: doverskog m. J Hepatol. 2021 Jul;75(1):98-107. doi: 10.1016/j.jhep.2021.03.012. Epub 2021 Apr 21. J Hepatol. 2021. PMID: 33894327 Free article. Clinical Trial.
25 results