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Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.
Front Pharmacol. 2024 Mar 15;15:1358323. doi: 10.3389/fphar.2024.1358323. eCollection 2024.
Front Pharmacol. 2024.
PMID: 38560359
Free PMC article.
Review.
Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.
Arenas YM, Izquierdo-Altarejos P, Martinez-García M, Giménez-Garzó C, Mincheva G, Doverskog M, Jones DEJ, Balzano T, Llansola M, Felipo V.
Arenas YM, et al. Among authors: mincheva g.
Liver Int. 2024 Feb;44(2):433-445. doi: 10.1111/liv.15782. Epub 2023 Nov 27.
Liver Int. 2024.
PMID: 38010893
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Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus.
Leone P, Arenas YM, Balzano T, Mincheva G, Martinez-Garcia M, Montoliu C, Llansola M, Felipo V.
Leone P, et al. Among authors: mincheva g.
Eur J Neurol. 2023 Oct;30(10):3032-3046. doi: 10.1111/ene.15935. Epub 2023 Jul 4.
Eur J Neurol. 2023.
PMID: 37340928
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Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
Mincheva G, Gimenez-Garzo C, Izquierdo-Altarejos P, Martinez-Garcia M, Doverskog M, Blackburn TP, Hällgren A, Bäckström T, Llansola M, Felipo V.
Mincheva G, et al.
CNS Neurosci Ther. 2022 Nov;28(11):1861-1874. doi: 10.1111/cns.13926. Epub 2022 Jul 26.
CNS Neurosci Ther. 2022.
PMID: 35880480
Free PMC article.
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Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation.
Leone P, Mincheva G, Balzano T, Malaguarnera M, Felipo V, Llansola M.
Leone P, et al. Among authors: mincheva g.
Biomedicines. 2022 May 28;10(6):1263. doi: 10.3390/biomedicines10061263.
Biomedicines. 2022.
PMID: 35740285
Free PMC article.
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