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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Among authors: tate ew. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases.
Kallemeijn WW, Lueg GA, Faronato M, Hadavizadeh K, Goya Grocin A, Song OR, Howell M, Calado DP, Tate EW. Kallemeijn WW, et al. Among authors: tate ew. Cell Chem Biol. 2019 Jun 20;26(6):892-900.e4. doi: 10.1016/j.chembiol.2019.03.006. Epub 2019 Apr 18. Cell Chem Biol. 2019. PMID: 31006618 Free PMC article.
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.
Alzahofi N, Welz T, Robinson CL, Page EL, Briggs DA, Stainthorp AK, Reekes J, Elbe DA, Straub F, Kallemeijn WW, Tate EW, Goff PS, Sviderskaya EV, Cantero M, Montoliu L, Nedelec F, Miles AK, Bailly M, Kerkhoff E, Hume AN. Alzahofi N, et al. Among authors: tate ew. Nat Commun. 2020 Jul 13;11(1):3495. doi: 10.1038/s41467-020-17212-6. Nat Commun. 2020. PMID: 32661310 Free PMC article.
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Kallemeijn WW, Lanyon-Hogg T, Panyain N, Goya Grocin A, Ciepla P, Morales-Sanfrutos J, Tate EW. Kallemeijn WW, et al. Among authors: tate ew. Nat Protoc. 2021 Nov;16(11):5083-5122. doi: 10.1038/s41596-021-00601-6. Epub 2021 Oct 27. Nat Protoc. 2021. PMID: 34707257 Review.
Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry.
Priyamvada L, Kallemeijn WW, Faronato M, Wilkins K, Goldsmith CS, Cotter CA, Ojeda S, Solari R, Moss B, Tate EW, Satheshkumar PS. Priyamvada L, et al. Among authors: tate ew. PLoS Pathog. 2022 Oct 10;18(10):e1010662. doi: 10.1371/journal.ppat.1010662. eCollection 2022 Oct. PLoS Pathog. 2022. PMID: 36215331 Free PMC article.
193 results