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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Among authors: vernia s. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Guerrero A, et al. Among authors: vernia s. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. Nat Metab. 2019. PMID: 31799499 Free PMC article.
XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence.
Innes AJ, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, Porreca RM, Dharmalingam G, Vernia S, Zuber J, Vannier JB, García-Escudero R, Gil J. Innes AJ, et al. Among authors: vernia s. Genes Dev. 2021 Mar 1;35(5-6):379-391. doi: 10.1101/gad.343269.120. Epub 2021 Feb 18. Genes Dev. 2021. PMID: 33602872 Free PMC article.
Detection of senescence using machine learning algorithms based on nuclear features.
Duran I, Pombo J, Sun B, Gallage S, Kudo H, McHugh D, Bousset L, Barragan Avila JE, Forlano R, Manousou P, Heikenwalder M, Withers DJ, Vernia S, Goldin RD, Gil J. Duran I, et al. Among authors: vernia s. Nat Commun. 2024 Feb 3;15(1):1041. doi: 10.1038/s41467-024-45421-w. Nat Commun. 2024. PMID: 38310113 Free PMC article.
Endothelial sensing of AHR ligands regulates intestinal homeostasis.
Wiggins BG, Wang YF, Burke A, Grunberg N, Vlachaki Walker JM, Dore M, Chahrour C, Pennycook BR, Sanchez-Garrido J, Vernia S, Barr AR, Frankel G, Birdsey GM, Randi AM, Schiering C. Wiggins BG, et al. Among authors: vernia s. Nature. 2023 Sep;621(7980):821-829. doi: 10.1038/s41586-023-06508-4. Epub 2023 Aug 16. Nature. 2023. PMID: 37586410 Free PMC article.
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.
Paterson HAB, Yu S, Artigas N, Prado MA, Haberman N, Wang YF, Jobbins AM, Pahita E, Mokochinski J, Hall Z, Guerin M, Paulo JA, Ng SS, Villarroya F, Rashid ST, Le Goff W, Lenhard B, Cebola I, Finley D, Gygi SP, Sibley CR, Vernia S. Paterson HAB, et al. Among authors: vernia s. Nat Metab. 2022 Dec;4(12):1812-1829. doi: 10.1038/s42255-022-00681-y. Epub 2022 Dec 19. Nat Metab. 2022. PMID: 36536133 Free PMC article.
Career pathways, part 14.
Rambold A, Vernia S. Rambold A, et al. Among authors: vernia s. Nat Metab. 2024 May 31. doi: 10.1038/s42255-024-01056-1. Online ahead of print. Nat Metab. 2024. PMID: 38822027 No abstract available.
41 results