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RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine.
Miskelly MG, Lindqvist A, Piccinin E, Hamilton A, Cowan E, Nergård BJ, Del Giudice R, Ngara M, Cataldo LR, Kryvokhyzha D, Volkov P, Engelking L, Artner I, Lagerstedt JO, Eliasson L, Ahlqvist E, Moschetta A, Hedenbro J, Wierup N. Miskelly MG, et al. Diabetologia. 2024 Feb;67(2):356-370. doi: 10.1007/s00125-023-06046-8. Epub 2023 Nov 30. Diabetologia. 2024. PMID: 38032369 Free PMC article.
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system.
Chu L, Terasaki M, Mattsson CL, Teinturier R, Charbord J, Dirice E, Liu KC, Miskelly MG, Zhou Q, Wierup N, Kulkarni RN, Andersson O. Chu L, et al. Among authors: miskelly mg. Cell Chem Biol. 2022 Sep 15;29(9):1368-1380.e5. doi: 10.1016/j.chembiol.2022.08.001. Epub 2022 Aug 22. Cell Chem Biol. 2022. PMID: 35998625 Free PMC article.
Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels.
Lindqvist A, Shcherbina L, Prasad RB, Miskelly MG, Abels M, Martínez-Lopéz JA, Fred RG, Nergård BJ, Hedenbro J, Groop L, Hjerling-Leffler J, Wierup N. Lindqvist A, et al. Among authors: miskelly mg. Mol Cell Endocrinol. 2020 Jul 1;511:110835. doi: 10.1016/j.mce.2020.110835. Epub 2020 May 3. Mol Cell Endocrinol. 2020. PMID: 32371087 Free article.
11 results