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Page 1
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg RJBHN, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M. Jiang M, et al. Among authors: florea bi. Nat Commun. 2023 Dec 5;14(1):8039. doi: 10.1038/s41467-023-43606-3. Nat Commun. 2023. PMID: 38052772 Free PMC article.
Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C. Reichelt J, et al. Among authors: florea bi. Nat Commun. 2023 Apr 28;14(1):2453. doi: 10.1038/s41467-023-38206-0. Nat Commun. 2023. PMID: 37117182 Free PMC article. No abstract available.
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
Paone P, Latousakis D, Terrasi R, Vertommen D, Jian C, Borlandelli V, Suriano F, Johansson MEV, Puel A, Bouzin C, Delzenne NM, Salonen A, Juge N, Florea BI, Muccioli GG, Overkleeft H, Van Hul M, Cani PD. Paone P, et al. Among authors: florea bi. Gut. 2024 May 13:gutjnl-2023-330301. doi: 10.1136/gutjnl-2023-330301. Online ahead of print. Gut. 2024. PMID: 38740509 Free article.
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.
Schaftenaar FH, van Dam AD, de Bruin G, Depuydt MAC, de Mol J, Amersfoort J, Douna H, Meijer M, Kröner MJ, van Santbrink PJ, Bernabé Kleijn MNA, van Puijvelde GHM, Florea BI, Slütter B, Foks AC, Bot I, Rensen PCN, Kuiper J. Schaftenaar FH, et al. Among authors: florea bi. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1346-1364. doi: 10.1161/ATVBAHA.123.319701. Epub 2024 Apr 25. Arterioscler Thromb Vasc Biol. 2024. PMID: 38660806
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration.
Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, Wedekind U, Sachs M, Zieliniski S, Brand J, Conze C, Florea BI, Heppner F, Krüger E, Rinschen MM, Kretz O, Thünauer R, Meyer-Schwesinger C. Sachs W, et al. Among authors: florea bi. Nat Commun. 2024 Mar 1;15(1):1897. doi: 10.1038/s41467-024-46273-0. Nat Commun. 2024. PMID: 38429282 Free PMC article.
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.
Kuo CL, Su Q, van den Nieuwendijk AMCH, Beenakker TJM, Offen WA, Willems LI, Boot RG, Sarris AJ, Marques ARA, Codée JDC, van der Marel GA, Florea BI, Davies GJ, Overkleeft HS, Aerts JMFG. Kuo CL, et al. Among authors: florea bi. Org Biomol Chem. 2023 Oct 4;21(38):7813-7820. doi: 10.1039/d3ob01261a. Org Biomol Chem. 2023. PMID: 37724332
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C. Reichelt J, et al. Among authors: florea bi. Nat Commun. 2023 Apr 13;14(1):2114. doi: 10.1038/s41467-023-37836-8. Nat Commun. 2023. PMID: 37055432 Free PMC article.
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.
Bakker AT, Kotsogianni I, Mirenda L, Straub VM, Avalos M, van den Berg RJBHN, Florea BI, van Wezel GP, Janssen APA, Martin NI, van der Stelt M. Bakker AT, et al. Among authors: florea bi. J Am Chem Soc. 2023 Jan 18;145(2):1136-1143. doi: 10.1021/jacs.2c10819. Epub 2022 Dec 30. J Am Chem Soc. 2023. PMID: 36584241 Free PMC article.
141 results