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Integration of datasets for individual prediction of DNA methylation-based biomarkers.
Merzbacher C, Ryan B, Goldsborough T, Hillary RF, Campbell A, Murphy L, McIntosh AM, Liewald D, Harris SE, McRae AF, Cox SR, Cannings TI, Vallejos CA, McCartney DL, Marioni RE. Merzbacher C, et al. Among authors: murphy l. Genome Biol. 2023 Dec 5;24(1):278. doi: 10.1186/s13059-023-03114-5. Genome Biol. 2023. PMID: 38053194 Free PMC article.
Genetic and environmental exposures constrain epigenetic drift over the human life course.
Shah S, McRae AF, Marioni RE, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Starr JM, Wray NR, Deary IJ, Visscher PM. Shah S, et al. Among authors: murphy l. Genome Res. 2014 Nov;24(11):1725-33. doi: 10.1101/gr.176933.114. Epub 2014 Sep 23. Genome Res. 2014. PMID: 25249537 Free PMC article.
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.
Marioni RE, Shah S, McRae AF, Ritchie SJ, Muniz-Terrera G, Harris SE, Gibson J, Redmond P, Cox SR, Pattie A, Corley J, Taylor A, Murphy L, Starr JM, Horvath S, Visscher PM, Wray NR, Deary IJ. Marioni RE, et al. Among authors: murphy l. Int J Epidemiol. 2015 Aug;44(4):1388-96. doi: 10.1093/ije/dyu277. Epub 2015 Jan 22. Int J Epidemiol. 2015. PMID: 25617346 Free PMC article.
DNA methylation age of blood predicts all-cause mortality in later life.
Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Feinberg AP, Fallin MD, Multhaup ML, Jaffe AE, Joehanes R, Schwartz J, Just AC, Lunetta KL, Murabito JM, Starr JM, Horvath S, Baccarelli AA, Levy D, Visscher PM, Wray NR, Deary IJ. Marioni RE, et al. Among authors: murphy l. Genome Biol. 2015 Jan 30;16(1):25. doi: 10.1186/s13059-015-0584-6. Genome Biol. 2015. PMID: 25633388 Free PMC article.
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.
Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR, Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundström J, Gustafsson S, Shah S, McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E, Lipovich L, Visscher PM, Wray NR, Krauss RM, Fallin D, Feinberg A, Absher DM, Fornage M, Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ. Mendelson MM, et al. Among authors: murphy l. PLoS Med. 2017 Jan 17;14(1):e1002215. doi: 10.1371/journal.pmed.1002215. eCollection 2017 Jan. PLoS Med. 2017. PMID: 28095459 Free PMC article.
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
Harris SE, Riggio V, Evenden L, Gilchrist T, McCafferty S, Murphy L, Wrobel N, Taylor AM, Corley J, Pattie A, Cox SR, Martin-Ruiz C, Prendergast J, Starr JM, Marioni RE, Deary IJ. Harris SE, et al. Among authors: murphy l. Aging (Albany NY). 2017 Dec 1;9(12):2489-2503. doi: 10.18632/aging.101333. Aging (Albany NY). 2017. PMID: 29207374 Free PMC article.
Identification of 55,000 Replicated DNA Methylation QTL.
McRae AF, Marioni RE, Shah S, Yang J, Powell JE, Harris SE, Gibson J, Henders AK, Bowdler L, Painter JN, Murphy L, Martin NG, Starr JM, Wray NR, Deary IJ, Visscher PM, Montgomery GW. McRae AF, et al. Among authors: murphy l. Sci Rep. 2018 Dec 4;8(1):17605. doi: 10.1038/s41598-018-35871-w. Sci Rep. 2018. PMID: 30514905 Free PMC article.
Assessment of dried blood spots for DNA methylation profiling.
Walker RM, MacGillivray L, McCafferty S, Wrobel N, Murphy L, Kerr SM, Morris SW, Campbell A, McIntosh AM, Porteous DJ, Evans KL. Walker RM, et al. Among authors: murphy l. Wellcome Open Res. 2019 Mar 6;4:44. doi: 10.12688/wellcomeopenres.15136.1. eCollection 2019. Wellcome Open Res. 2019. PMID: 30984878 Free PMC article.
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936.
Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, Selvaraj BT, Browne C, Svendsen CN, Cowley SA, Deary IJ, Chandran S, Spires-Jones TL, Sareen D. Toombs J, et al. Among authors: murphy l. Stem Cell Res. 2020 Jul;46:101851. doi: 10.1016/j.scr.2020.101851. Epub 2020 May 20. Stem Cell Res. 2020. PMID: 32450543 Free PMC article.
Epigenetic predictors of lifestyle traits applied to the blood and brain.
Gadd DA, Stevenson AJ, Hillary RF, McCartney DL, Wrobel N, McCafferty S, Murphy L, Russ TC, Harris SE, Redmond P, Taylor AM, Smith C, Rose J, Millar T, Spires-Jones TL, Cox SR, Marioni RE. Gadd DA, et al. Among authors: murphy l. Brain Commun. 2021 Apr 19;3(2):fcab082. doi: 10.1093/braincomms/fcab082. eCollection 2021. Brain Commun. 2021. PMID: 34041477 Free PMC article.
1,992 results