Wells JA - Search Results

1

Extracellular targeted protein degradation: an emerging modality for drug discovery.

Wells JA, Kumru K. Wells JA, et al. Nat Rev Drug Discov. 2024 Feb;23(2):126-140. doi: 10.1038/s41573-023-00833-z. Epub 2023 Dec 7. Nat Rev Drug Discov. 2024. PMID: 38062152 Review.

2

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Wells JA, McClendon CL. Wells JA, et al. Nature. 2007 Dec 13;450(7172):1001-9. doi: 10.1038/nature06526. Nature. 2007. PMID: 18075579 Review.

3

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins.

Pance K, Gramespacher JA, Byrnes JR, Salangsang F, Serrano JC, Cotton AD, Steri V, Wells JA. Pance K, et al. Among authors: wells ja. Nat Biotechnol. 2023 Feb;41(2):273-281. doi: 10.1038/s41587-022-01456-2. Epub 2022 Sep 22. Nat Biotechnol. 2023. PMID: 36138170 Free PMC article.

4

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Arkin MR, Wells JA. Arkin MR, et al. Among authors: wells ja. Nat Rev Drug Discov. 2004 Apr;3(4):301-17. doi: 10.1038/nrd1343. Nat Rev Drug Discov. 2004. PMID: 15060526 Review. No abstract available.

5

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Ostrem JM, et al. Among authors: wells ja. Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20. Nature. 2013. PMID: 24256730 Free PMC article.

6

Enzyme-catalyzed expressed protein ligation.

Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Henager SH, et al. Nat Methods. 2016 Nov;13(11):925-927. doi: 10.1038/nmeth.4004. Epub 2016 Sep 26. Nat Methods. 2016. PMID: 27669326 Free PMC article.

7

Subtiligase-Catalyzed Peptide Ligation.

Weeks AM, Wells JA. Weeks AM, et al. Among authors: wells ja. Chem Rev. 2020 Mar 25;120(6):3127-3160. doi: 10.1021/acs.chemrev.9b00372. Epub 2019 Oct 30. Chem Rev. 2020. PMID: 31663725 Review.

8

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1.

Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. Cotton AD, et al. Among authors: wells ja. J Am Chem Soc. 2021 Jan 20;143(2):593-598. doi: 10.1021/jacs.0c10008. Epub 2021 Jan 4. J Am Chem Soc. 2021. PMID: 33395526 Free PMC article.

9

Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins.

Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA. Gramespacher JA, et al. Among authors: wells ja. ACS Chem Biol. 2022 May 20;17(5):1259-1268. doi: 10.1021/acschembio.2c00185. Epub 2022 Apr 28. ACS Chem Biol. 2022. PMID: 35481357

10

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.

Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP. Ferguson ID, et al. Among authors: wells ja. Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6. Nat Commun. 2022. PMID: 35840578 Free PMC article.

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