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SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells.
Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Hengstschläger M, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ. Celada SI, et al. Among authors: tsoyi k. Sci Transl Med. 2023 Sep 13;15(713):eade2581. doi: 10.1126/scitranslmed.ade2581. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703351
Targeting Danger Signals to Rescue Fibrosis.
Tsoyi K, Rosas IO. Tsoyi K, et al. Am J Respir Cell Mol Biol. 2022 May;66(5):468-470. doi: 10.1165/rcmb.2022-0022ED. Am J Respir Cell Mol Biol. 2022. PMID: 35271415 Free PMC article. No abstract available.
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO. Tsoyi K, et al. Sci Rep. 2022 Feb 18;12(1):2847. doi: 10.1038/s41598-022-06678-7. Sci Rep. 2022. PMID: 35181688 Free PMC article.
Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA. Han J, et al. Among authors: tsoyi k. FEBS J. 2022 Jan;289(2):417-435. doi: 10.1111/febs.16154. Epub 2021 Aug 15. FEBS J. 2022. PMID: 34355516 Free PMC article.
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. Sun B, et al. Among authors: tsoyi k. Matrix Biol. 2021 Aug;102:70-84. doi: 10.1016/j.matbio.2021.07.001. Epub 2021 Jul 15. Matrix Biol. 2021. PMID: 34274450 Free PMC article.
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO. Tsoyi K, et al. Am J Respir Crit Care Med. 2021 Aug 1;204(3):312-325. doi: 10.1164/rccm.202008-3100OC. Am J Respir Crit Care Med. 2021. PMID: 33784491 Free PMC article.
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models.
Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS. Hettiarachchi SU, et al. Among authors: tsoyi k. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. doi: 10.1126/scitranslmed.aay3724. Sci Transl Med. 2020. PMID: 33115948
Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis.
Zhang F, Ayaub EA, Wang B, Puchulu-Campanella E, Li YH, Hettiarachchi SU, Lindeman SD, Luo Q, Rout S, Srinivasarao M, Cox A, Tsoyi K, Nickerson-Nutter C, Rosas IO, Low PS. Zhang F, et al. Among authors: tsoyi k. EMBO Mol Med. 2020 Aug 7;12(8):e12034. doi: 10.15252/emmm.202012034. Epub 2020 Jun 29. EMBO Mol Med. 2020. PMID: 32597014 Free PMC article.
35 results