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Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs).
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku SR, Gordon-Blake JM, Laham MS, Christie N, Ma N, Fu J, Xiong R, Courey JM, Velma GR, Thatcher GRJ. Shen Z, et al. Among authors: ackerman berrier m. J Med Chem. 2023 Dec 28;66(24):16704-16727. doi: 10.1021/acs.jmedchem.3c01406. Epub 2023 Dec 14. J Med Chem. 2023. PMID: 38096366 Free article.
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Ratia KM, Shen Z, Gordon-Blake J, Lee H, Laham MS, Krider IS, Christie N, Ackerman-Berrier M, Penton C, Knowles NG, Musku SR, Fu J, Velma GR, Xiong R, Thatcher GRJ. Ratia KM, et al. Among authors: ackerman berrier m. Biochemistry. 2023 Feb 21;62(4):923-933. doi: 10.1021/acs.biochem.2c00655. Epub 2023 Feb 6. Biochemistry. 2023. PMID: 36746631 Free PMC article.
Efficient discovery of inhibitory ligands for diverse targets from a small combinatorial chemical library of chimeric molecules.
Thorpe DS, Edith Chan AW, Binnie A, Chen LC, Robinson A, Spoonamore J, Rodwell D, Wade S, Wilson S, Ackerman-Berrier M, Yeoman H, Walle S, Wu Q, Wertman KF. Thorpe DS, et al. Among authors: ackerman berrier m. Biochem Biophys Res Commun. 1999 Dec 9;266(1):62-5. doi: 10.1006/bbrc.1999.1775. Biochem Biophys Res Commun. 1999. PMID: 10581165