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A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. Lee E, et al. Among authors: polacheck wj. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2308941120. doi: 10.1073/pnas.2308941120. Epub 2023 Oct 2. Proc Natl Acad Sci U S A. 2023. PMID: 37782785 Free PMC article.
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.
Aw WY, Cho C, Wang H, Cooper AH, Doherty EL, Rocco D, Huang SA, Kubik S, Whitworth CP, Armstrong R, Hickey AJ, Griffith B, Kutys ML, Blatt J, Polacheck WJ. Aw WY, et al. Among authors: polacheck wj. Sci Adv. 2023 Feb 15;9(7):eade8939. doi: 10.1126/sciadv.ade8939. Epub 2023 Feb 15. Sci Adv. 2023. PMID: 36791204 Free PMC article.
43 results