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Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.
Jindal S, Pedersen DV, Gera N, Chandler J, Patel R, Neill A, Cone J, Zhang Y, Yuan CX, Millman EE, Carlin D, Puffer B, Sheridan D, Andersen GR, Tamburini P. Jindal S, et al. Among authors: pedersen dv. Mol Immunol. 2024 Jan;165:29-41. doi: 10.1016/j.molimm.2023.12.004. Epub 2023 Dec 23. Mol Immunol. 2024. PMID: 38142486 Free article.
Bispecific Complement Engagers for Targeted Complement Activation.
Pedersen DV, Gytz H, Winkler MBL, Zarantonello A, Baumann N, Hansen AG, Thiel S, Andersen GR, Valerius T, Laursen NS. Pedersen DV, et al. J Immunol. 2023 Aug 1;211(3):403-413. doi: 10.4049/jimmunol.2200952. J Immunol. 2023. PMID: 37350633
Nanobody-mediated complement activation to kill HIV-infected cells.
Pedersen ML, Pedersen DV, Winkler MBL, Olesen HG, Søgaard OS, Østergaard L, Laursen NS, Rahimic AHF, Tolstrup M. Pedersen ML, et al. Among authors: pedersen dv. EMBO Mol Med. 2023 Apr 11;15(4):e16422. doi: 10.15252/emmm.202216422. Epub 2023 Feb 17. EMBO Mol Med. 2023. PMID: 36799046 Free PMC article.
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.
Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GR. Pedersen H, et al. Among authors: pedersen dv. J Immunol. 2020 Oct 15;205(8):2287-2300. doi: 10.4049/jimmunol.2000752. Epub 2020 Sep 16. J Immunol. 2020. PMID: 32938727
16 results