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Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
Ku TC, Cao J, Won SJ, Guo J, Camacho-Hernandez GA, Okorom AV, Salomon KW, Lee KH, Loland CJ, Duff HJ, Shi L, Newman AH. Ku TC, et al. Among authors: duff hj. ACS Pharmacol Transl Sci. 2024 Jan 5;7(2):515-532. doi: 10.1021/acsptsci.3c00322. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357284
Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes.
Janz A, Walz K, Cirnu A, Surjanto J, Urlaub D, Leskien M, Kohlhaas M, Nickel A, Brand T, Nose N, Wörsdörfer P, Wagner N, Higuchi T, Maack C, Dudek J, Lorenz K, Klopocki E, Ergün S, Duff HJ, Gerull B. Janz A, et al. Among authors: duff hj. Mol Metab. 2024 Jan;79:101859. doi: 10.1016/j.molmet.2023.101859. Epub 2023 Dec 23. Mol Metab. 2024. PMID: 38142971 Free PMC article.
The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.
Kudaibergenova M, Guo J, Khan HM, Lees-Miller J, Mousaei M, Miranda W, Ngo VA, Noskov SY, Tieleman DP, Duff HJ. Kudaibergenova M, et al. Among authors: duff hj. Biophys J. 2022 Dec 6;121(23):4585-4599. doi: 10.1016/j.bpj.2022.10.032. Epub 2022 Oct 29. Biophys J. 2022. PMID: 36815709 Free PMC article.
Lipid regulation of hERG1 channel function.
Miranda WE, Guo J, Mesa-Galloso H, Corradi V, Lees-Miller JP, Tieleman DP, Duff HJ, Noskov SY. Miranda WE, et al. Among authors: duff hj. Nat Commun. 2021 Mar 3;12(1):1409. doi: 10.1038/s41467-021-21681-8. Nat Commun. 2021. PMID: 33658490 Free PMC article.
Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation.
Janz A, Chen R, Regensburger M, Ueda Y, Rost S, Klopocki E, Günther K, Edenhofer F, Duff HJ, Ergün S, Gerull B. Janz A, et al. Among authors: duff hj. Stem Cell Res. 2020 Jul;46:101856. doi: 10.1016/j.scr.2020.101856. Epub 2020 Jun 2. Stem Cell Res. 2020. PMID: 32521499 Free article.
Selectivity filter modalities and rapid inactivation of the hERG1 channel.
Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. Miranda WE, et al. Among authors: duff hj. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2795-2804. doi: 10.1073/pnas.1909196117. Epub 2020 Jan 24. Proc Natl Acad Sci U S A. 2020. PMID: 31980532 Free PMC article.
211 results