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Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes.
Janz A, Walz K, Cirnu A, Surjanto J, Urlaub D, Leskien M, Kohlhaas M, Nickel A, Brand T, Nose N, Wörsdörfer P, Wagner N, Higuchi T, Maack C, Dudek J, Lorenz K, Klopocki E, Ergün S, Duff HJ, Gerull B. Janz A, et al. Among authors: lorenz k. Mol Metab. 2024 Jan;79:101859. doi: 10.1016/j.molmet.2023.101859. Epub 2023 Dec 23. Mol Metab. 2024. PMID: 38142971 Free PMC article.
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Schmid E, et al. Among authors: lorenz k. Nat Med. 2015 Nov;21(11):1298-306. doi: 10.1038/nm.3972. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479924
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic A, Brand T, Schanbacher C, Kramer S, Hümmert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knüchel R, Müller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Müller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Tomasovic A, et al. Among authors: lorenz k. Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4. Nat Commun. 2020. PMID: 32265441 Free PMC article.
Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.
Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E, Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-Armouche A, Sossalla S, Kämmerer S. Wagner M, et al. Among authors: lorenz k. Int J Mol Sci. 2021 May 1;22(9):4816. doi: 10.3390/ijms22094816. Int J Mol Sci. 2021. PMID: 34062838 Free PMC article.
Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice.
Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. Gil-Pulido J, et al. Among authors: lorenz k. Cardiovasc Res. 2022 Nov 10;118(14):2932-2945. doi: 10.1093/cvr/cvab359. Cardiovasc Res. 2022. PMID: 34897380
Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells.
Tolstik E, Gongalsky MB, Dierks J, Brand T, Pernecker M, Pervushin NV, Maksutova DE, Gonchar KA, Samsonova JV, Kopeina G, Sivakov V, Osminkina LA, Lorenz K. Tolstik E, et al. Among authors: lorenz k. Front Pharmacol. 2022 Aug 9;13:962763. doi: 10.3389/fphar.2022.962763. eCollection 2022. Front Pharmacol. 2022. PMID: 36016563 Free PMC article.
994 results